GENERAL PATHOLOGY

Degree course: 
Corso di Long single cycle degree (6 years) in School of Dentistry
Academic year when starting the degree: 
2015/2016
Year: 
2
Academic year in which the course will be held: 
2015/2016
Course type: 
Compulsory subjects, characteristic of the class
Credits: 
6
Period: 
Second semester
Standard lectures hours: 
36
Detail of lecture’s hours: 
Lesson (36 hours)
Requirements: 

Biochemistry, cell biology

Final Examination: 
Orale
Assessment: 
Voto Finale

Course objectives
The General Pathology course provides the students with the fundamentals of modern cellular and molecular pathology, as well as of multicellular degenerative pathologic processes, inflammation and neoplasia. Part of the course is dedicated to understanding the mechanisms of innate and acquired immunity. The course includes indications on applications in clinical pathology.

Content and program of the course
General concepts in pathology
Etiology: the intrinsic and extrinsic causes of disease, examples of mechanisms of action of chemical or physical agents, inadequate nutrition, poisons; genetic alterations and hereditary diseases, morphologic and functional alterations and the concepts of cellular alterations, causes of cellular damage, and cell death: necrosis and apoptosis
Cellular adaptation, growth and differentiation; atrophy hypotrophy/hypoplasia; hypertrophy; hyperplasia; metaplasia
The genetic basis of diseases
The inflammatory response: acute inflammation, chronic inflammation, inflammation associated pathologies, hypersensitivities, general concepts of organ specific and systemic autoimmune diseases
Cancer: Cell cycle control, nomenclature and classes of cancers, benign and malignant tumors, physical, chemical and viral carcinogenesis, genetics and cancer, oncogenes and oncosuppressors, definition and epidemiological evidence for multi-stage carcinogenesis, metastasis.
Immunity; the innate immune response, cellular and chemical defense barriers; acquired immunity – lymphoid organs, cellular and chemical mediators, the humoral response and immunoglobulin classes, cell mediated responses, specificity, diversity and memory in the immune response, the major histocompatability complex – polymorphisms and function in transplant rejection, active and passive immunity, acquired and congenital immuno-deficiencies.
Physiopathology of the cardiovascular system and the oral cavity
Concepts of Clinical Pathology
Type of didactic activities
lessons

Text books and other didactic materials
Cotran, Kumar, Collins – “Robbins – The Pathologic Basis of Disease”
Verification of what the student learned
Oral exam