Students must have completed their exams in inorganic and organic chemistry, biochemistry, physiology.
Course description and learning objectives
Objectives: Students will be enabled to master the major concepts of toxicokinetics and toxicodynamics, and the basic topics of biochemical toxicology and molecular toxicology. A section of the course will also illustrate several important classes of toxic compounds and their mechanisms of action at the organ, tissue, cellular and molecular levels. At the end of the course, the student will possess the basic tools for further studies in pharmacology and toxicology.
The students are evaluated by a written exam, consisting of 1-3 open questions.
-Toxicokinetics and pharmacokinetics: administration routes, adsorption, distribution, biotransformation and excretion of toxins and drugs
-Toxins active on major biochemical pathways in the cell: glycolysis, Pyruvate dehydrogenase complex, Krebs cycle, electron transfer chain.
-Basic information on the genetic determinants of the response to toxins.
-Chemical structure, mechanism of action and molecular/cellular/systemic effects of:
2-Dioxins, Furans, Polychlorinated biphenyls
3-Organic solvents: benzene
4-Radioactive compounds and ionizing radiation
5-Drugs: Salycilates, Aminoglycosides, Cyclophosphamyde, Chloramphenicol, etc.
7-Chemical carcinogens: nitrosamines, nitroso-compounds, base analogues, etc.
8-Metals: Lead, Mercury, Chromium.
Casarett and Doull’s Toxicology, 8th edition ISBN13: 978-0071769235
ISBN10: 0071769234; Publisher: McGraw-Hill Publishing Company Published: 2013