PATHOPHYSIOLOGY OF THE CENTRAL NERVOUS SYSTEM

Degree course: 
Corso di Second cycle degree in BIOMEDICAL SCIENCES
Academic year when starting the degree: 
2020/2021
Year: 
1
Academic year in which the course will be held: 
2020/2021
Course type: 
Supplementary compulsory subjects
Language: 
English
Credits: 
6
Period: 
Second semester
Standard lectures hours: 
48
Detail of lecture’s hours: 
Lesson (48 hours)
Requirements: 

Good knowledge of Physiology and Neurophysiology in particular

Final Examination: 
Orale
Assessment: 
Voto Finale

This course aims at providing the basic knowledge regarding the structural and functional organization of the Central Nervous system
At the end of the course, the student will be capable of:
-- Understanding how the molecular and cellular processes in neurons and glia and the organization of neural circuits give rise to sensory information processing, motor control, sleep, memory, learning, emotions, language, thought and motivated behavior
-- describing the specific features of Central Nervous System pathophysiology, of the neuron-glia interaction, of the processes of neurodegeneration and of possible strategies of neuroprotection
-- Understanding how genetic and environmental factors and psychological experience may interact in generating neurological and psychic disturbances.
-- explaining the modalities of onset and the main features of the most important CNS pathologies (Parkinson's, Huntington's, Alzheimer's diseases, epilepsy and migraine, ALS, Schizophrenia, Depression, Bipolar Spectrum Disorders, Autistic Spectrum Disorders, ADHD)
-- defining the main Neuroscience research approaches for studying CNS Pathologies and developing their therapies.

CONTENTS
1. Overview of the CNS and cellular aspect, the functional aspect and the pathology in this system
2. Synaptology
3. Neurotransmitters in the CNS
4. Neuromodulation and neuronal computing
5. Neuronal and Synaptic plasticity
6. Neuronal development and degeneration. Glia and Neurons
7. The organization of the cerebral cortex
8. Sensory system and central processing of sensory information
9. Motor control
10. Multiple Sclerosis (MS)
11. Cerebellum and basal ganglia
12. Amyotrophic Lateral Sclerosis (ALS)
13. Parkinson’s Disease (PD)
14. Huntington Disease (HD)
15. Alzheimer’s Disease (AD)
16. The limbic system
17. Depression, Bipolar Spectrum Disorders, Post Traumatic Stress Disorder (PTSD).
18. Migraine and Epilepsy
19. Physiopathology of memory and learning, and Consciousness
20. Schizophrenia
21. Autistic Spectrum Disorders (ASD), Attention Deficit Hyperactive Disorder (ADHD)

Convenzionale