GENERAL PATHOLOGY

Degree course: 
Corso di First cycle degree in Dental Hygiene
Academyc year when starting the degree: 
2018/2019
Year: 
1
Academyc year when helding the course: 
2018/2019
Credits: 
3
Period: 
Second semester
Standard lectures hours: 
36
Requirements: 

Knowledges of Anatomy, Biology, Basic Chemistry and Biochemistry are required

Assessment: 
Voto Finale

The course of Human Physiology provides the Students with all information needed to understand, from the biophysical and quantitative standpoint, the mechanisms of functioning of body organs and systems and their control performed by the central and autonomic nervous system and by the endocrine system.

The General Pathology course provides the students with the fundamentals of modern cellular and molecular pathology. The course deals with the investigation of those pathological mechanisms common to all tissue-cell pathology; Etiology, Pathogenesis, Morphologic changes, Functional derangements and clinical significance. Attention is paid to the processes of cellular adaptation, cell death, cellular accumulation, tissue repair, inflammation, immunology and immunopathology, and neoplasia. This course takes the basic science that the student has learned in previous courses to clinical concepts.

HUMAN PHYSIOLOGY
Resting membrane potential. Action potential and its propagation. Synapses and neuromuscular junction. Afferent sensory systems. Neuromuscular spindles and Golgi receptors. Thermal and pain sensitivity. Neuromotor units. Spinal reflexes. Motor control, function of cortical areas.
Skeletal muscle. Myogram. Force-length diagram. Force-velocity diagram. Dynamic force-velocity diagram.
Blood volume and its distribution. Velocity, cross section and pressure in the circulatory districts. Mechanical features of blood vessels. Bernoulli and Poiseuille laws. Cardiac excictability. Cardiac mechanics. Work and mechanical efficiency of the heart. Arterial and venous pulse pressure in systemic and pulmonary circulations. Fluid and solute exchanges between microvasculature and interstitial space. Lymph formation and propulsion. Oedema. Pulmonary circulation. Control of cardiovascular function
Air composition and respiratory gasses. Spirometry, static lung volumes. Pulmonary and alveolar volume and flow. Respiratory mechanics.. Respiratory ratio. Alveolar gas equation.. Respiratory gas exchange and their transport in blood. Nervous and chemical control of respiratory function.
Renal function. Glomerular filtration. Renal clearance. Absorption of water, Na+, Cl-, bicarbonates, aminoacids, urea. Secretion of H+ and organic substances. Henle loop and vasa recta. Distal convolute and collecting tubules. Aldosterone and vasopressin. Regulation of volume and osmoticity in extracellular body fluids. Urine volume, pH and composition.
Physiological buffer solutions. Respiratory and metabolic acidosis and alkalosis and their compensation.
Metabolism. Energetic fuel: anaerobic and aerobic pathways. Energy available in food. Oxygen debt. Basal, rest ad exercise metabolism. O2 consumption.
Peristaltic movements. Composition and functions of salivary, gastric, hepatic, pancreatic and intestinal secretion. Control of secretions. Digestion and absorption of carbohydrates, proteins, lipids, ions, vitamins, drugs and water.
Mechanisms of hormone release and action in the pituitary gland, adrenal glands, thyroid, paratyroids, pancreas

GENERAL PATHOLOGY
- extrinsic causes, examples and mechanisms of action of physical and chemical agents as well as poisons and nutritional factors
- Intrinsic causes, inheritance and examples of genetic diseases.
Pathogenesis, morphological changes and functional alterations cellular alteration concepts
- causes of cell damage
- cellular adaptation, growth and differentiation; atrophy hypotrophy/hypoplasia; hypertrophy; hyperplasia; metaplasia
- Cell death: necrosis and apoptosis
- Healing and repair of injuries
- Immunity and the immune system
- The inflammatory response: acute inflammation, chronic inflammation, inflammation associated pathologies, the innate immune response, cellular and chemical defense barriers
- Acquired immunity: lymphoid organs, cellular and chemical mediators, the humoral response and immunoglobulin classes, cell mediated responses, specificity, diversity and memory in the immune response, the major histocompatability complex, Vaccines, active and passive immunity, acquired and congenital immuno-deficiencies.
- Hypersensitivities, general concepts of organ specific and systemic autoimmune diseases, transplant rejection
- Cancer: Cell cycle control, nomenclature and classes of cancers, benign and malignant tumors, physical, chemical and viral carcinogenesis, genetics and cancer, oncogenes and oncosuppressors, definition and epidemiological evidence for multi-stage carcinogenesis, metastasis.
- General concepts of physiopathology of the cardiovascular system and the oral cavity
- General concepts of Clinical Pathology

HUMAN PHYSIOLOGY
- AA.VV. – FISIOLOGIA DELL'UOMO - a cura di P.E Di Prampero e A. Veicsteinas - Casa Editrice Edi-Ermes, Milano
- AA.VV. – FISIOLOGIA – a cura di P.Scotto, P. Mondola - Poletto Editore, Milano

GENERAL PATHOLOGY
“G.M. PONTIERI: Elementi di PATOLOGIA GENERALE per i Corsi di Laurea in Professioni Sanitarie. Piccin