PHARMACOLOGY

Degree course: 
Corso di First cycle degree in Biomedical Laboratory techniques
Academyc year when starting the degree: 
2018/2019
Year: 
2
Academyc year when helding the course: 
2019/2020
Course type: 
Basic compulsory subjects
Credits: 
1
Period: 
First Semester
Standard lectures hours: 
12
Detail of lecture’s hours: 
Lesson (12 hours)
Requirements: 

Basic knowledge of anatomy and biochemistry

The achievement of the course objectives will be assessed through an oral exam concerning the course contents.

Assessment: 
Voto Finale

Course aims are to achieve a good knowledge about principles and phases of preclinical and clinical experimentations. In particular pre-clinical trials (objectives, used techniques with examples and results evaluations). Principles and phases of clinical trials. Setting up of clinical trials. Definitions and role of ethics committees. Examples of clinical trials. Drug bioequivalence. Adverse drug Reaction. Toxicology studies. Classification of the toxic substances. Mechanism of action of toxic substances. Antidotes.

Development and testing of drug. Principles and stages of preclinical drugs trial. Preparation of pre-clinical trials, targets of pre-clinical trials. Techniques for the realization of pre-clinical trials with examples. Examples of pre-clinical trials. Principles and phases of clinical trials. Preparation of linical tria Preparation of pharmacological study. Role of ethics committees in clinical trials. Objectives of clinical trials. Phases of clinical trials. examples of clinical trial: experimental determination of bioequivalence. adverse reaction concept. Toxicology studies. Classification of the toxic substances. Mechanism of action of toxic substances. Antidotes.

Principles and stages of preclinical testing of drugs.
- Definition of preclinical study, Phase I and Phase II,
- EC50 Definition,
- Subacute and chronic toxicity studies.
- Techniques for the study of pharmacological receptors.
- Examples of pre-clinical experimental protocols.
Principles and phases of clinical trials of drugs.
- Preparation of clinical studies
- The role of ethics committee in clinical trials
- Phases of clinical trial
- Clinical trials Examples: experimental determination of drugs bioequivalence
- Clinical trials Examples: concept of adverse drug reaction (ADR), examples of side effects drug induced.
- Toxicology studies.
- Classification of the toxic substances. - Mechanism of action of toxic substances.
- Antidotes.

-Furlanut M Farmacologia generale e clinica per le lauree triennali. Piccin, Padova
-Neal MJ Medical Pharmacology at a Glance Blackwell Scientific Publications, Oxford (trad. italiana a cura di Richelmi P, Berté F La Farmacologia in uno Sguardo La Goliardica Pavese, Pavia)
-Clementi F, Fumagalli G Farmacologia generale e molecolare UTET, Torino, 2000
-Craig CR, Stitzel RE Farmacologia moderna con applicazioni cliniche, Antonio Delfino Editore, Roma
-Katzung BG Farmacologia generale e clinica. Piccin, Padova
-Rang HP, Dale MM, Ritter JM Farmacologia Casa Editrice Ambrosiana, Milano

Convenzionale

Frontal lessons, supported by the use of powerpoint slides.

Professors

Parent course