GENERAL PATHOLOGY

Degree course: 
Corso di First cycle degree in Biomedical Laboratory techniques
Academyc year when starting the degree: 
2018/2019
Year: 
2
Academyc year when helding the course: 
2019/2020
Course type: 
Compulsory subjects, characteristic of the class
Credits: 
2
Period: 
First Semester
Standard lectures hours: 
24
Detail of lecture’s hours: 
Lesson (24 hours)
Requirements: 

Basic knowledge of Biology

Refer to the content of the entire integrated course

Assessment: 
Voto Finale

Refer to the content of the entire integrated course

Students will learn the basic notions of cellular and molecular pathology, and the pathologic processes at the basis of multicellular degeneration, inflammation and tumor development. The course will focus also on the innate and adaptive immunity. Special emphasis will be given to acute and chronic inflammation and to related diseases, to the pathogenesis of AIDS and to the neoplastic process

General notions of Pathology:
Etiology (extrinsic causes, mechanisms of action of chemical and physical agents; intrinsic causes, genetic diseases)
Pathogenesis, Morphological and functional modifications
Cellular modifications (causes of cellular damage, necrosis, apoptosis)
Cell growth and differentiation (atrophy, hypertrophy, hypoplasia, hyperplasia, metaplasia)
Inflammation (acute inflammation: vascular and cellular modifications, chemotactic mediators, regeneration and repair of the lesion; chronic inflammation: histology, cellular infiltration, tubercular granuloma)
Inflammation-related diseases: Allergy (type I, II, III, IV), organ specific and systemic autoimmune diseases.
Innate and Adaptive Immunity: lymphoid organs, cells and mediators of the humoral and cellular responses, Major Histocompatibility Complex: polymorphism, function and role in the rejection of transplanted organs. Examples of congenic immunodeficiencies.
Pathogenesis of AIDS
- HIV infection: receptors, co-receptors and cellular targets
- Immune dysfunctions in HIV infection
- Clinical course of HIV infection
Oncology: control of cellular proliferation, anaplasia, tumors classifications; benign and malignant tumors; carcinogenesis: physical and chemical agents, oncogenic viruses; oncogenes and tumor suppressor genes; monoclonality of tumors; multistep carcinogenesis; the metastatic process

1. Elementi di patologia generale per i corsi di laurea in professioni sanitarie
Pontieri (piccin)
2. Patologia generale, rubin l’essenziale
Rubin E. (Piccin)
3. le basi patologiche delle malattie
Robbins (Piccin)
4. introduzione all’immunologia
Actor J.K. (Pearson)
5. come funziona il sistema immunitario
Sompayrac l. (Piccin)
6. immunologia, biologia e patologia del sistema immunitario
Maniero F., Palmieri G., Paolini R. (Piccin)
7. Abbas, Lichtman, Pober, “Immunologia Cellulare e Molecolare” (Elsevier)
Educational material (es.: in e-learning, slides, scientific manuscripts,..): Copy of the slides

Refer to the content of the entire integrated course

Refer to the content of the entire integrated course

Professors

Parent course