Degree course: 
Corso di Long single cycle degree (6 years) in MEDICINE AND SURGERY
Academic year when starting the degree: 
Academic year in which the course will be held: 
Course type: 
Basic compulsory subjects
First Semester
Standard lectures hours: 
Detail of lecture’s hours: 
Lesson (80 hours), Exercise (16 hours)

To attend the course the student should have positively passed the biochemistry 1.

Final Examination: 

The exam of biochemistry has a single note that is obtained after passing the exam of biochemistry 2 and represents the average of the votes of biochemsitry 1 and 2. The exam will have to be supported in two separate tests on different dates, the first will focus on the topics of biochemistry 1 and the second will focus on topics of biochemistry 2. The average of the two exams will constitute the final grade. However, in order to take the biochemical 2 exam, the student must have successfully passed the biochemical exam 1.
The exam for the biochemistry module 2 consists of a written test and an oral exam. The written test consists of 30 multiple-choice questions (five possible answers, one or more of which is true and to be identified by the student) regarding the comprehension of the topics covered. The evaluation will be insufficient if the correct answers will be less than 18. The note is not reduced by incorrect answers. The oral exam will be supported only by students who have successfully passed the written exam and will consist of questions related to the written test.
For the oral exams, the minimum to pass the exam is 18/30. During the exam the student will be evaluated considering his knowledge and understanding ( 25 % ), the ability to apply knowledge and understanding ( 25 % ) , his independent judgment ( 15 % ), the communication skills ( 15 % ) and the ability to learn ( 20 % ) in relation to curse program.
The final vote of biochemistry will be the average of the notes of biochemistry 1 and 2.

Voto Finale

The course aims at providing a complete overview of the structural characteristics and functional properties of the main biomolecules of biomedical interest, to understand the alterations that may cause diseases.
The course will address a complete overview of the fundamental principles of specific metabolisms of human tissues in normal and pathological conditions including the fundamentals of cellular bioenergetics, the structure and mechanisms of nucleic acid replication, the mechanisms of control of gene expression and the processes of protein synthesis and hormone activity. The subject of the course will also be the scientific basis of medical procedures and the operating principles of the instruments used in diagnostic and therapeutic practice. The adjustments of the main metabolic pathways, the molecular mechanisms of cellular activity regulation will be an integral part of the program. At the end of the course the student must be able to recognize the potential and the limits of the main cellular and molecular and genetic biology techniques.
The approach is mainly based on the biochemistry point of view.

Principal metabolic pathways and regulation: metabolism of cholesterol, aminoacids and heme. Metabolism of nucleotides and nucleic acids. Metabolism of glycoproteins. Biochemistry of signal transduction in cells. Biochemistry of hormones. Biochemistry of tissues: liver, kidney, blood and vessels, bones and muscles, nervous system, adipose tissues. Biochemistry of extracellular matrix. Biochemistry of transcriptional and post transcriptional control of energy, epigenetic and metabolism. Biochemistry of tumors.

Respiratory chain and oxidative phosphorylation, Biosynthesis of lipids and cholesterol and their regulation. Amino acid metabolism; transamination and transdesamination. Defensive mechanisms against ammonia, glutamine biosynthesis and urea cycle. Metabolic adaptation during starvation. Cancer. Cell signalling.
Heme and bilirubin metabolism. Nucleotide synthesis and catabolism.
Hormones: general properties and mechanisms. Hormones functions of hypothalamus hypophysis axis, steroids, insulin, glucagon, adrenaline.

Bassi, Boffi et al.

Siliprandi, Tettamanti.
Biochimica medica.

Nelson, Cox.
I principi di biochimica di Lehninger.

Berg, Tymoczko, Stryer.

Biochimica con aspetti clinici


The course is organized with lectures that provide for slide projections (usually in English). During the explanation in the classroom the students are invited to interact with the teachers with questions and curiosity. During the lectures the teachers will also present cases and daily facts that can make the application / importance of the subjects of the teachings understand. Students have the obligation to attend classes as established in the educational regulations of the study course and to sign the time sheet for taking the exam. Teachers undertake to make projected presentations available to lectures and other material of interest (articles) through the University computer platforms (e-learning) to which students have access. In the teacher's presentations there will be links to web pages for further information.

Student reception: appointment by e-mail (