PROF Karousou Jenny
None in particular, do not forget the arithmetic of the primary school, especially equivalents and proportions.
BIOLOGY AND GENETICS
The objective of the course is to present the hereditary laws of the transmission of the physiological and pathological characters and the diagnostic approach based on current technology the medical personnel have to apply to study the hereditary diseases.
PROF Jenny Karousou
Knowing the chemical basis of biological phenomena, mostly those important in physiology, diseases, and clinical practice, at the level of cells, tissues and total body. Approaching the own language and method of experimental life sciences.
1 Mendel laws and exceptions.
2 Mytosis, Meiosis, , Chromosomal sex determination
3 Chromosomal theory of heredity, X-Linked transmission.
4 Linkage complete and incomplete
5 DNA: function structure e duplication, Cromatine ed Heterocromatine
6 RNA structure and maturation, Proteic sysntesis, Genetic code;
7 Human normal and pathologic karyotype
8 Chromosomal and genic mutations
9 Autosomal dominant and recessive transmission, X-linked transmission.
10 Mary Lyon;
11 Uniparental disomy , genomic inprinting
12 Molecular and molecular cytogenetic techniques.
13 Human chromosomal pathologies, S. di Down, Patau, Edwards, Sindrome of partial trisomie or monosomy of the autosomes;
14 Human chromosomal pathologies, of the X chromosomes S. Klinefelter, Polisomies of the X e Y chromosomes;
15 Chromosomal instability syndromes.
16 Genes and tumors
1) CHEMICAL BONDS. Covalent and ionic bonding, molecules and crystals
2) SOLUTIONS. Water properties, solvation and electrolytes, hydrogen bond, concentration of the solutions.
3) ACID-BASE BALANCE. Fundamentals (strength of the acids and the bases pH, pK), buffering, biological buffers, Handerson-Hasselbalch equation
4) BIOENERGETICS (I). Principles of the thermodynamics, free energy and spontaneous reactions, high-energy bonds.
5) BIOENERGETICS (II). Redox potentials, redox pairs of particular biological importance, oxidative phosphorylation.
6) ENZYMES. Reaction rate and chemical equilibrium, catalysts and biological catalysis, specificity and control of enzymatic reactions
7) ORGANIC COMPOUNDS. Functional groups: alcohol, aldehydes, ketones, carboxyl acids, amines. Nomenclature and main characteristics. Main types of isomers. Aromatic compounds.
8) LIPIDS. Fatty acids, triglycerides and phospholipids. Detergents and micelles. NUCLEIC ACIDS. Nitrogenous bases and nucleotides, DNA and RNA
9) CARBOHYDRATES. Monosaccharides, pentoses, hexoses, anomers and epimers; glycosidic bond, di- and polysaccharides
10) AMINOACIDS AND PROTEINS. General structure and properties of the main side chains. Peptide bond and protein structure.
All didactic material presented in the classes as well the one necessary for the preparation of the examination (slides, pantries, exercises) is available in the e-learning platform.