Università degli studi dell'Insubria

VIGETTI DAVIDE

VIGETTI DAVIDE

Professore Associato
Orario di ricevimento:

Please send an email to davide.vigetti@uninsubria.it.

Phone
0332 21 7170

DAVIDE VIGETTI, Ph.D.

Department of Surgical and Morphological Sciences

School of Medicine - University of Insubria

Via Dunant, 5 - 21100 Varese

ITALY

 

tel. ++39-0332-397170

fax. ++39-0332-397119

 

email: davide.vigetti@uninsubria.it

 

EDUCATION

Davide Vigetti has been in the scientific and organizing committees of several national and international meetings:

AWARDS

RESEARCH ACTIVITIES

 

  • 1994-1996 nutrient regulation of Saccharomyces cerevisiae cell cycle
  • 1997-2003 nitrogen excretion pathway in Xenopus laevis
  • 1997-2003 heavy metal ions toxicity in Xenopus laevis development
  • 2004-present Set up of quantitative methods to quantify glycosaminoglycans.
  • 2004- present Extracellular matrix metabolism in cultures of human cells in senescence.
  • 2004-present Regulation of hyaluronic acid synthesis in in vitro models of human pathologies as atherosclerosis and cancers.
  • 2014-present Epigenetic regulation of gene expression (long non-coding RNA biology).

BIBLIOGRAPHY

Davide Vigetti is author of 78 peer reviewed papers with total impact factor of more than 250, more than 2100 citations, and a H-index is 26 (from Scopus database).

He attended more than 60 scientific meetings presenting about 20 talks as invited or selected speaker or chair.
Briefly:

  • Gordon Research Conference on Proteoglycans 2012 (poster selected for oral presentation).
  • International Conference on Hyaluronan Sciences 2003, 2007, 2013, 2019 (poster selected for oral presentation, invited speaker and session chair).
  • FEBS Advanced Lecture Course Matrix Pathobiology 2013, 2015 (poster selected for oral presentation).
  • FEBS Advanced Lecture Course Matrix Pathobiology 2018 (Discussion leader and invited speaker).
  • Italian Congress of Biochemistry and Molecular Biology 2003, 2005, 2010, 2011, 2015 (poster selected for oral presentation).
  • Italian Congress of Biochemistry and Molecular Biology 2007, 2013 (invited speaker).
  • Italian Congress of Connective Tissue Studies 2006, 2016 (poster selected for oral presentation).
  • Italian Congress of Connective Tissue Studies 2018 (invited speaker).
     

SELECTED PUBLICATIONS

For a complete list of PubMed publications click here

 

  1. Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, Vigetti D, Passi A, Hatano S, Umezawa K, Watanabe H. (2018) The plant alkaloid conophylline inhibits matrix formation of fibroblasts J Biol Chem. 293, 20214-20226
  2. Vigetti D, Caon I, Passi A. (2018) A nutrient sentinel stands guard outside the cell. J Biol Chem. 293:16951-16952. Editors' Picks
  3. Karamanos NK, Piperigkou Z, Theocharis AD, Watanabe H, Franchi M, Baud S, Brézillon S, Götte M, Passi A, Vigetti D, Ricard-Blum S, Sanderson RD, Neill T, Iozzo RV (2018) Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics. Chem Rev. 118:9152-9232.
  4. Filpa V, Bistoletti M, Caon I, Moro E, Grimaldi A, Moretto P, Baj A, Giron MC, Karousou E, Viola M, Crema F, Frigo G, Passi A, Giaroni C, Vigetti D. (2017) Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis. Sci Rep.;7:17644
  5. Viola M, Karousou E, D'Angelo ML, Moretto P, Caon I, Luca G, Passi A, Vigetti D. (2017) Extracellular Matrix in Atherosclerosis: Hyaluronan and Proteoglycans Insights. Curr Med Chem. 23:2958-2971
  6. Moretto P, Karousou E, Viola M, Caon I, D’Angelo ML, De Luca G, Passi A, Vigetti D (2015) Regulation of hyaluronan synthesis in vascular diseases and diabetes. Journal of Diabetes Research Article ID 167283, 9 pages
  7. Vigetti D, Deleonibus S, Moretto P, Bowen T, Fischer JW, Grandoch M, Oberhuber A, Love DC, Hanover JA, Cinquetti R, Karousou E, Viola M, D’Angelo ML, HAscall VC, De Luca G, Passi A (2014) Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. J Biol Chem. 289:28816-28826
    (comment on Matrix Biology highlights)
  8. Vigetti D, Viola M, Karousou E, Deleonibus S, Karamanou K, De Luca G, Passi A (2014) Epigenetic in extracellular matrix remodeling and hyaluronan metabolism. FEBS J. 281:4980–4992
  9. Vigetti D, Karousou E, Viola M, Deleonibus S, De Luca G, Passi A (2014) Hyaluronan: biosynthesis and signaling. Biochim Biophys Acta - General Subjects 1840: 2452-2459
  10. Viola M, Bartolini B, Vigetti D, Karousou E, Moretto P, Deleonibus S, Sawamura T, Wight TN, Hascall VC, De Luca G, Passi A. (2013) Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells. J Biol Chem. 288:29595-29603
  11. Vigetti D, Deleonibus S, Moretto P, Karousou E, Viola M, Bartolini B, Hascall VC, Tammi MI, De Luca G, Passi A (2012) Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis. J Biol Chem. 287: 35544-35555
  12. Vigetti D, Rizzi M, Moretto P, Clerici M, Dreyfuss JM, Karousou E, Viola M, Deleonibus S, Hascall VC, Ramoni MF, De Luca G, Passi A. (2011). Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells. J Biol Chem. 286:34497-34503
  13. Vigetti D, Clerici M, Deleonibus S, Karousou E, Viola M, Moretto P, Heldin P, Hascall VC, De Luca G, Passi A. (2011) Hyaluronan synthesis is inhibited by adenosine monophosphate activated protein kinase through the regulation of hyaluronan synthase 2 activity in human aortic smooth muscle cells. J Biol Chem. 286(10):7917-7924
  14. Acquati F, Bertilaccio S, Grimaldi A, Monti L, Cinquetti R, BonettI P, Lualdi M,  Vidalino L, Fabbri M, Sacco MG, Van Rooijen N, Campomenosi P, Vigetti D, Passi A, Riva C, Capella C, Sanvito F, Doglioni C, Gribaldo L, Macchi P, Sica A, Noonan D, Ghia P, Taramelli R. (2011) Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proc Natl Acad Sci U S A 108:1104-1109
  15. Vigetti D, Genasetti A, Karousou E, Viola M, Clerici M, Deleonibus S, De Luca G, Hascall VC, Passi A. (2010) Proinflammatory cytokines induce hyaluronan synthesis and monocytes adhesion in human endothelial cells through has2 and NF-kB pathway. J Biol Chem. 285:24639-24645
  16. Vigetti D, Genasetti A, Karousou E, Viola M, Clerici M, Bartolini B, Moretto P, De Luca G, Hascall VC, Passi A. (2009) Modulation of hyaluronan synthase activity in cellular membrane fractions. J Biol Chem. 284(44):30684-94.
  17. Vigetti D, Rizzi M, Viola M, Karousou E, Genasetti A, Clerici M, Bartolini B, Hascall VC, De Luca G, Passi A. (2009) The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2 activity, proliferation, and motility of human aortic  smooth muscle cells. Glycobiology. 19(5):537-46.
  18. Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, Clerici M, Hascall VC, De Luca G, Passi A. (2008) Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. J Biol Chem. 283(7):4448-58.
  19. Vigetti D, Moretto P, Viola M, Genasetti A, Rizzi M, Karousou E, Pallotti F, De Luca G, Passi A. (2006) Matrix metalloproteinase 2 and tissue inhibitors of metalloproteinases regulate human aortic smooth muscle cell migration during in vitro aging. FASEB J. 20(8):1118-30.
  20. Vigetti D, Ori M, Viola M, Genasetti A, Karousou E, Rizzi M, Pallotti F, Nardi I, Hascall VC, De Luca G, Passi A. (2006) Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis. J Biol Chem. 281(12):8254-63.

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