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The University of Insubria
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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Daniela Furlan
The University of Insubria CV
 

Contact data

Assistant Professor of Pathology
Department of Human Morphology
Via O.Rossi 9 21100-Varese, Italy
Tel: +390332264557
Fax: +390332262313
E-mail: daniela.furlan@uninsubria.it
 

Biography

 -1 1986-1990: Masters in Biological Sciences (Molecular Biology), University of Pavia. Masters dissertation on Bacterial Genetics

-2 1991-1992: Italian Association for Cancer Research (AIRC) fellowship on a project of murine monoclonal antibodies humanization by genetic engineering at Experimental Oncology Div. E of “ Istituto Nazionale per lo Studio e la Cura dei tumori” (Milano)

-3 1993-2000. Technician at Dept. of Clinical and Biological Sciences of the University of Pavia at Varese (since July 1998 University of Insubria) as responsible for the implementation of the Molecular Biology laboratory within the Anatomic Pathology laboratory.

-4 2001-present: Assistant Professor, Anatomic Pathology laboratory, Dept of Human Morphology of the University of Insubria. Research activity on Molecular Oncology projects
 

Qualifications and awards

 1991 Italian Qualifying Examination for Board Certified Biologist, Pavia, Italy

2003 Residency in Applied Genetics, University of Pavia
 

Research interests

 The main fields of interest and research are:

-1 Minimal deletion regions of chromosome 6 in benign and borderline tumors of ovary

-2 Pathogenetic mechanisms of solid tumors with microsatellite instability

-3 Monoclonal and policlonal origin of mixed and collision endocrine-exocrine tumors of the gut

-4 Molecular profile of well and poorly differentiated endocrine tumors of various sites
 

Teaching experience and appointments

 -1 School of Medicine, Undergraduate Course “BIOMEDICAL LABORATORY TECHNIQUES”. Class: ANATOMIC PATHOLOGY

-2 School of Medicine, Undergraduate Course “BIOMEDICAL LABORATORY TECHNIQUES”. Class: MOLECULAR BIOLOGY APPLIED TO ANATOMIC PATHOLOGY

-3 School of Sciences, Undergraduate Course “BIOTECHNOLOGY” Class: CLINICAL PATHOLOGY
Representative publications
 

Representative  publications

 1. MG.Tibiletti, B.Bernasconi, D.Furlan, C.Riva, M.Trubia, G.Buraggi, M.Franchi, PF.Bolis, A.Mariani, L.Frigerio, C.Capella, R.Taramelli Early involvement of 6q in Surface Epithelial Ovarian Tumors. Cancer Res 56(19): 4493-4498, (1996)

2. MG.Tibiletti, B.Bernasconi, M.Taborelli, D.Furlan, A.Fabbri, M.Franchi, R.Taramelli, M.Trubia and C.Capella. Involvement of chromosome 6 in endometrial cancer. Br J Cancer 75(12): 1831-1835 (1997)

3. MG. Tibiletti, M.Trubia, E.Ponti, L.Sessa, F.Acquati, D.Furlan, B.Bernasconi, M.Fichera, A.Mihalich, A.Ziegler, A.Volz, C.Facco, C.Riva, L.Cremonesi, M.Ferrari and R.Taramelli. Physical map of the D6S149-D6S193 region on chromosome 6q27 and its involvement in benign surface epithelial ovarian tumors. Oncogene 16: 1639-1642 (1998)

4. D.Furlan, M.G.Tibiletti, M.Taborelli, L.Albarello, M.Cornaggia and C.Capella The value of microsatellite instability in the detection of HNPCC families and of sporadic colorectal cancers with special biological features: an investigation on a series of 100 consecutive cases. indro of Oncology 9: 901-906 (1998)

5. M.G.Tibiletti, D.Furlan, M.Taborelli, C.Facco, C.Riva, M.Franchi, A.Cossu, M.Trubia, R.Taramelli, C.Capella Microsatellite instability in endometrial cancer: relation to histological subtypes Gynecol Oncol 73: 247-52 (1999)

6. F.Bertoni, A.M. Coregoni A.M., D.Furlan, M.G.Tibiletti, C.Capella, M.Broggini CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. Genes, Chromosomes and Cancer 26: 176-180 (1999).

7. D.Furlan, F.Bertoni, R.Cerutti, M.Taborelli, G.Pinotti, E.Roggero, F.Cavalli, M.Bonato, E.Zucca, C.Capella Microsatellite instability in gastric MALT lymphomas and other associated neoplasms. Annals of Oncology 10: 783-788 (1999).

8. MG.Tibiletti, F.Sessa, B.Bernasconi, R.Cerutti, B.Broggi, D.Furlan, F.Acquati, M.Bianchi, C.Capella and R.Taramelli. A large 6q deletion is a common cytogenetic alteration in fibroadenomas, pre-malignant lesions and carcinomas of the breast. Clin Cancer Res 6(4): 1422-31 (2000)

9. A.M. Chiaravalli, D. Furlan, C. Facco, M.G. Tibiletti, A. Dionigi, B. Casati, L. Albarello, C. Riva, C. Capella. Immunohistochemical pattern of Hmsh2/Hmlh1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. Virchows Arch 438: 39-48 (2001).

10. A.M. Chiaravalli, M. Cornaggia, D. Furlan, C. Capella, R. Fiocca, G. Tagliabue, C. Klersy, E. Solcia. The role of histological investigation in prognostic evaluation of advanced gastric cancer. Analysis of histological structure and molecular changes compared with invasive pattern and stage. Virchows Arch 439: 158-69 (2001).

11. M.G.Tibiletti, B.Bernasconi, D.Furlan, P.Bressan, R. Cerutti, C.Facco, M. Franchi, C. Riva, R. Cinguetti R., C.Capella, R.Taramelli. Chromosome 6 abnormalities in ovarian surface epithelial tumors of borderline malignancy suggest a genetic continuum in the progression model of ovarian neoplasms. Clin Cancer Res 7: 3404-9 (2001).

12. D. Furlan, B. Casati, R. Cerutti, C. Facco, L.G. Terracciano, C. Capella, A.M. Chiaravalli. Study of genetic progression in sporadic endometrial and gastrointestinal cancers with high microsatellite instability. J Pathology 197: 603-9 (2002).

13. N. Suraweera, A. Duval, M. Reperant, C. Vaury, D. Furlan, K. Leroy, R. Seruca, B. Iacopetta, R. Hamelin. Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology 123: 1804-11 (2002).

14. F. Sessa, D. Furlan, A. Genasetti, P. Billo, M. Feltri, C. Capella. Microsatellite instability and p53 expression in gallbladder carcinomas. Diagn Mol Pathos 12: 96-102 (2003).

15. D. Furlan, R. Cerutti, A. Genasetti, G. Pelosi, S. Uccella, S. La Rosa, C. Capella. Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut. Lab Invest 83: 963-71 (2003).

16. S. La Rosa, D. Furlan, F. Sessa, C.Capella. “The Endocrine Pancreas.” In: R.V. Lloyd eds. Endocrine Pathology . Differential Diagnosis and Molecular Advances. Totowa, New Jersey, Humana Press, 2003: 291-328

17. D. Furlan, R. Cerutti, S. Uccella, S. La Rosa, E. Rigoli, A. Genasetti, C. Capella. Different molecular profiles characterize well differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract. Clin Cancer Res. 10: 947-957 (2004)

18. D. Furlan, Barbara Bernasconi, Silvia Uccella, Roberta Cerutti, Ileana Carnevali, and Carlo Capella. Allelotypes and FISH profiles of poorly differentiated endocrine carcinomas of different sites. Clin Cancer Res. 11: 1765-1775 (2005)

19. Chiaravalli AM, Feltri M, Bertolini V, Bagnoli E, Furlan D, Cerutti R, Novario R, Capella C. Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection. Virchows Arch. 2005 Oct 27;:1-10

20. Agostini M, Tibiletti MG, Lucci-Cordisco E, Chiaravalli A, Morreau H, Furlan D, Boccuto L, Pucciarelli S, Capella C, Baiocchi M, Viel A. Two PMS2 mutations in a Turcot syndrome family with small bowel cancers. Am J Gastroenterol. 2005 Aug;100(8):1886-91
 

Clinical interests

1. Colorectal carcinoma
2. Poorly differentiated endocrine carcinoma
3. Human Papilloma Virus in cervical neoplasia

 
 
   
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