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Contact data |
Full Professor
of Pathology |
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Biography |
1966-1968: Resident in
Pathology, University Hospital S. Matteo, Pavia 1968-1983: Assistant Professor of Anatomic Pathology, University Hospital S. Matteo, Pavia 1983-1990: Associate Professor of Anatomic Pathology, University of Pavia at Varese Since 1983: Head of the Institute of Anatomic Pathology, University Hospital of Varese Since 1990: Full Professor of Anatomic Pathology, University of Pavia at Varese and (from 1998) University of Insubria, Varese Since 1996: Director of the Postgraduate Medical School of Pathology, School of Medicine, University of Insubria, Varese, Italy Since 1999: Director of the Postgraduate Medical School of Oncology, School of Medicine, University of Insubria, Varese, Italy 1998-2001: Chairman Department of Clinical Pathology, University Hospital of Varese Since 2004: Chairman of the Oncologic Department of the University Hospital of Varese |
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Qualifications and awards |
Member of the Scientific
Societies and Committees: International Academy of Pathology European Society of Pathology International Endocrine Pathology Society Pituitary Pathologists Club American College of Gastroenterology Italian Society of Pathology (SIAPEC) Italian Work Group of Gastroenteropancreatic Neuroendocrine Pathology Italian Society of Cancerology 1994-1996: Member of the WHO expert group of pathologists for the histological typing of pancreatic tumours 1996-2004: Member of the WHO expert group of pathologists for the histological typing of endocrine tumours Since 2004: Member of the European Board of Pathology (UEMS), Italian representative Member of the Committee of Central Instrument Facility for Biomedical Research and of the Biomedical Library of the University of Insubria. Member of the Editorial Board of: Virchows Archiv Tumori J Digest Protection |
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Research interests |
The main fields of interest and research are: endocrine tumors of the gastroenteropancreatic (GEP) tract, carcinomas and lymphomas of the stomach, colon-rectum and pancreas, carcinomas of the ovary and endometrium, pituitary adenomas. | |
Teaching experience and appointments |
The teaching activity of
Prof. C. Capella started in 1968 at the Medical School of the University
of Pavia, when he became Assistant Professor of Anatomic Pathology,
and continued when he became Associate Professor (in 1983) and Full
Professor in Varese (in 1990). The scholarly contributions include:
training of students and residents in autopsy pathology, cytopathology
and general plus subspeciality pathology including gastrointestinal
pathology, endocrine pathology, hematopathology and electron microscopy. The main teaching task of Prof. Capella is now the coordination of the course of Systemic Pathology for MD students of the year 4 and year 5 and the direction of pathology residency program and of medical oncology residency program at the University of Insubria School of Medicine. The training programs are designated to give students and residents expertise in pathology and in oncology. They also include knowledge and understanding the basic science behind the disease. |
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Representative publications |
CHIARAVALLI A.M, FELTRI
M, BERTOLINI V, BAGNOLI E, FURLAN D, CERUTTI R, NOVARIO R, CAPELLA
C. (2005). Intratumour T cells, their activation status and survival
in gastric carcinomas characterised for microsatellite instability
and Epstein-Barr virus infection. VIRCHOWS ARCH. Oct 27 pp. 1-10 FURLAN D, BERNASCONI B, UCCELLA S, CERUTTI R, CARNEVALI I, CAPELLA C. (2005). Allelotypes and fluorescence in situ hybridization profiles of poorly differentiated endocrine carcinomas of different sites. CLINICAL CANCER RESEARCH. vol. 11 pp. 1765-1775 FURLAN D, CERUTTI R, UCCELLA S, LA ROSA S, RIGOLI E, GENASETTI A, CAPELLA C. (2004). Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract. CLINICAL CANCER RESEARCH. vol. 10 pp. 947-957 LA ROSA S, RIGOLI E, UCCELLA S, CHIARAVALLI AM, CAPELLA C. (2004). CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. VIRCHOWS ARCHIV. vol. 445 pp. 248-254 LA ROSA S, UCCELLA S, MARCHET S, CAPELLA C., LLOYD RV. (2004). Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. vol. 52 pp. 217-225 FURLAN D, CERUTTI R, GENASETTI A, PELOSI G, UCCELLA S, LA ROSA S, CAPELLA C. (2003). Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut. LABORATORY INVESTIGATION. vol. 83 pp. 963-971 GIARONI C, ZANETTI E, CHIARAVALLI AM, ALBARELLO L, DOMINIONI L, CAPELLA C., LECCHINI S, FRIGO G. (2003). Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors. EUROPEAN JOURNAL OF PHARMACOLOGY. vol. 476 pp. 63-69 HRIBAL ML, PEREGO L, LOVARI S, ANDREOZZI F, MENGHINI R, PEREGO C, FINZI G, USELLINI L, PLACIDI C, CAPELLA C., GUZZI V, LAURO D, BERTUZZI F, DAVALLI A, POZZA G, PONTIROLI A, FEDERICI M, LAURO R, BRUNETTI A, FOLLI F, SESTI G. (2003). Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans. FASEB JOURNAL. vol.17 pp. 1340-1342 LA ROSA S, UCCELLA S, FINZI G, ALBARELLO L, SESSA F, CAPELLA C. (2003). Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. HUMAN PATHOLOGY. vol. 34 pp. 18-27 PONZONI M, FERRERI AJ, PRUNERI G, POZZI B, DELL'ORO S, PIGNI A, PINOTTI G, VILLA E, FRESCHI M, VIALE G, CAPELLA C. (2003). Prognostic value of bcl-6, CD10 and CD38 immunoreactivity in stage I-II gastric lymphomas: identification of a subset of CD10+ large B-cell lymphomas with a favorable outcome. INTERNATIONAL JOURNAL OF CANCER. vol. 106 pp. 288-291 PRUNERI G, FABRIS S, FASANI R, DEL CURTO B, CAPELLA C., POZZI B, MOTTA T, ANDREOLA S, FERRERI AJ, PONZONI M, VIALE G, NERI A. (2003). Immunoreactivity for cyclin D3 is frequently detectable in high-grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation. JOURNAL OF PATHOLOGY. vol. 200 pp. 596-601 SESSA F, FURLAN D, GENASETTI A, BILLO P, FELTRI M, CAPELLA C. (2003). Microsatellite instability and p53 expression in gallbladder carcinomas. DIAGNOSTIC MOLECULAR PATHOLOGY. vol. 12 pp. 96-102 TIBILETTI MG, BERNASCONI B, TABORELLI M, FACCO C, RIVA C, CAPELLA C., FRANCHI M, BINELLI G, ACQUATI F, TARAMELLI R (2003). Genetic and cytogenetic observations among different types of ovarian tumors are compatible with a progression model underlying ovarian tumorigenesis. CANCER GENETICS AND CYTOGENETICS. vol.146 pp. 145-153 BERTONI F., CONCONI A., CAPELLA C., MOTTA T., GIARDINI R., PONZONI M., PEDRINIS E., NOVERO D., RINALDI P., CAZZANIGA G., BIONDI A., WOTHERSPOON A., HANCOCK BW, SMITH P., SOUHAMI R., COTTER F.E., CAVALLI F., ZUCCA E. (2002). Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03cooperative trial. BLOOD. vol. 99 pp. 2541-2544 FURLAN D, CASATI B, CERUTTI R, FACCO C, TERRACCIANO L, CAPELLA C., CHIARAVALLI AM. (2002). Genetic progression in sporadic endometrial and gastrointestinal cancers with high microsatellite instability. JOURNAL OF PATHOLOGY. vol. 197 pp. 603-609 BEGHINI A., TIBILETTI M.G., ROVERSI G., CHIARAVALLI A.M., SERIO G., CAPELLA C., LARIZZA L. (2001). Germline mutation in the iuxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. CANCER. vol. 92 pp. 657-62 CHIARAVALLI A M, FURLAN D, FACCO C, TIBILETTI M G, DIONIGI A, CASATI B, ALBARELLO L, RIVA C, CAPELLA C. (2001). Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. VIRCHOWS ARCHIV. vol. 438 pp. 39-48 CHIARAVALLI A.M., CORNAGGIA M., FURLAN D., CAPELLA C., FIOCCA R., TAGLIABUE G., KLERSY C., SOLCIA E. (2001).The role of histological investigation in prognostic evaluation of advanced gastric cancer. Analysis of histological structure and molecular changes compared with invasive pattern and stage. VIRCHOWS ARCHIV. vol. 439 pp. 158-69 CONCONI A., BERTONI F., PEDRINIS E., MOTTA T., ROGGERO E., LUMINARI S., CAPELLA C., BONATO M., CAVALLI F., ZUCCA E. (2001). Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes. BLOOD. vol. 98 pp. 781-6 LA ROSA S, SESSA F, COLOMBO L, TIBILETTI MG, FURLAN D, CAPELLA C. (2001). Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. JOURNAL OF CLINICAL PATHOLOGY. vol. 54 pp. 37-41 TIBILETTI MG, BERNASCONI B., FURLAN D., BRESSAN P., CERUTTI R., FACCO C., FRANCHI M., RIVA C., CINQUETTI R., CAPELLA C., TARAMELLI R. (2001). Chromosome 6 abnormalities in ovarian surface epithelial tumors of borderline malignancy suggest a genetic continuum in the progression model of ovarian neoplasms. CLINICAL CANCER RESEARCH. vol. 7 pp. 3404-9 CAPELLA C., LA ROSA S, UCCELLA S, BILLO P, CORNAGGIA M. (2000). Mixed endocrine-exocrine tumors of the gastrointestinal tract. SEMINARS IN DIAGNOSTIC PATHOLOGY. vol. 17 pp. 91-103 TIBILETTI MG, SESSA F., BERNASCONI B., CERUTTI R., BROGGI B., FURLAN D., ACQUATI F., BIANCHI M., RUSSO A., CAPELLA C., TARAMELLI R. (2000). A large 6q deletion is a common cytogenetic alteration in fibroadenomas, pre-malignant lesions and carcinomas of the breast. CLINICAL CANCER RESEARCH. vol. 6 pp. 1422-31 BERTONI F, CODEGONI AM, FURLAN D, TIBILETTI MG, CAPELLA C., BROGGINI M. (1999). CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. GENES, CHROMOSOMES & CANCER. vol. 26 pp. 176-180 TIBILETTI M G, FURLAN D, TABORELLI M, FACCO C, RIVA C, FRANCHI M, COSSU A, TRUBIA M, TARAMELLI R, CAPELLA C. (1999). Microsatellite instability in endometrial cancer. Relation to histological subtypes. GYNECOLOGIC ONCOLOGY. vol. 73 pp. 247-252 FURLAN D, BERTONI F, CERUTTI R, TABORELLI M, PINOTTI G, ROGGERO E, CAVALLI F, BONATO M, ZUCCA E, CAPELLA C. (1999). Microsatellite instability in gastric MALT lymphomas and other associated neoplasm. ANNALS OF ONCOLOGY. vol. 10 pp. 783-788 SHIAO YH, BOVO D, GUIDO M, CAPELLA C., CASSARO M, BUSATTO G, RUSSO V, SIDONI A, PARENTI AR, RUGGE M. (1999). Microsatellite instability and/or loss of heterozygosity in young gastric cancer patients in Italy. INTERNATIONAL JOURNAL OF CANCER. vol. 82 pp. 59-62 FURLAN D, TIBILETTI M G, TABORELLI M, ALBARELLO L, CORNAGGIA M, CAPELLA C. (1998). The value of microsatellite instability in the detection of HNPCC families and sporadic colorectal cancers with special biological features: an investigation on a series of 100 consecutive cases. ANNALS OF ONCOLOGY. vol. 9 pp. 901-906 CAPELLA C., USELLINI L., PAPOTTI M., MACRI'L., FINZI G., EUSEBI V., BUSSOLATI G. (1990). Ultrastructural features of neuroendocrine differentiated carcinomas of the breast. ULTRASTRUCTURAL PATHOLOGY. vol. 14 pp. 321-334 PAPOTTI M., MACRI' L., FINZI G., CAPELLA C., EUSEBI V., BUSSOLATI G. (1989). Neuroendocrine differentiation in carcinoma of the breast. A study of 51 cases. SEMINARS IN DIAGNOSTIC PATHOLOGY. vol. 6 pp. 174-188 I |
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Clinical interests |
The main clinical interests
are in:
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