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Contact data |
Assistant Professor |
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Biography |
Born in Milan (Italy),
June 30, 1961, married and with three children Degree in Medicine, July 21, 1987, University of Milan Medical School (Italy), graduate thesis (biochemistry): "Re-cycling of the sialic acid residue of exogenous GM1 ganglioside in rat liver"; certification Exam for medical practice, December 1977, University of Milan Medical School Ph.D. in Biochemistry, June 1993, Ministry of University and scientific and technologic research, Rome (Italy), graduate thesis: "Development of approaches for the isolation of mammalian glycosyltransferase cDNAs by expression cloning" (work done at the University of Michigan) Recognition of Postdoctoral Training, September 1993, University of Michigan, Ann Arbor, Michigan (USA) Appointments Graduate student at the Department of Medical Chemistry and Biochemistry, University of Milan (Italy), from October 1983 to January 1988 Postdoctoral work at the Department of Chemistry (Biochemistry, Biophysics and Molecular Biology Program), Notre Dame University, Notre Dame, IN (USA), from February 1988 to September 1988 Postdoctoral fellowship as partial requirement for Ph.D. graduation in Biochemistry at the Department of Medical Chemistry and Biochemistry, University of Milan (Italy), from October 1988 to April 1991 Postdoctoral fellowship at the Department of Pathology, University of Michigan, Ann Arbor, Michigan, from May 1991 to May 1993 Postdoctoral fellowship at the Department of Clinical and Biological Sciences, University of Torino, from May 1994 to October 1995 Researcher (tenure-tracked permanent position) at the University of Pavia Medical School II, Department of Biochemistry, from November 16, 1995 to November 15, 1998 Assistant Professor (tenured) at the University of Insubria School of Medicine, Varese, Department of Biomedical Sciences Experimental and Clinical, from November 16, 1998 (present appointment) |
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Research interests |
Glycobiology. General: role of the carbohydrate chains of glycoproteins
and glycolipids in normal and pathologic processes. Specific: molecular biology
of glycosyltransferases in cancer Since 1996 leader of small research groups as the principal
investigator of different glycobiology research projects (see list below) Funded projects: Extramural: (1996) AIRC "Molecular cloning of glycosyltransferases which
synthesize tumor markers associated with malignancy"; (1997) Telethon "Molecular cloning of beta
1,3galactosyltransferase cDNA(s) responsible for the biosynthesis of epitopes
recognized by motor neuron disease patient sera"; (2001) COFIN "Molecular mechanisms regulating the expression of
CA19.9 and other adhesion molecules in colorectal cancer"; (2004) PRIN “Down-regulation of a galactosyltransferase gene:
molecular analysis and involvement in colorectal cancer malignancy. Intramural: (FARs 1997-1999) “Role of glycosyltransferases in normal and
pathologic state”; (FARs 2000-2002) “Relevance of specific glycosyltransferases in the
biosynthesis of active carbohydrates”; (FARs 2003-2004) “Role of galactosyltransferase b3Gal-T5 in the
expression of CA19.9 tumor antigen”; (FAR 2005) “Transcriptional regulation of b1,3 galactosyltransferase b3Gal-T5 in different tissues and cell lines”. |
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Teaching experience and appointments |
Associate to the Chair
of Medical Chemistry in MD program (include cycle of lessons, seminars,
exams as exam commission member, and full charge for graduate thesis)
since 1996 to date Chair of Medical Chemistry and propedeutical biochemistry in the integrated course of Medical Chemistry, Physics and Biology at the Nursing school (include full charge of lessons and exams as commission member) since 1998 to date Chair of medical Chemistry and propedeutical biochemistry in the integrated course of Chemistry and biology at the Technician school (include full charge of lessons and exams as commission president) since 2000 to date. |
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Representative publications |
M. Trinchera and R. Ghidoni, "Two glycosphingolipid
sialyltransferases are localized in different sub-Golgi compartments in rat
liver", (1989) J. Biol. Chem., 264, 15764-15769 M. Trinchera, R. Ghidoni, L. Greggia and G. Tettamanti, "The
N-acetylgalactosamine residue of exogenous GM2 ganglioside is recycled for
glycoconjugate biosynthesis in rat liver", (1990) Biochem. J. 266, 103-106 M. Trinchera and R. Ghidoni, "Subcellular biosynthesis and
transport of gangliosides formed from exogenous lactosylceramide in rat
liver", (1990) Biochem. J., 266, 363-369 M. Trinchera, R. Ghidoni, S. Sonnino and G. Tettamanti, "Recycling
of glucosylceramide and sphingosine for the biosynthesis of gangliosides and
sphingomyelin, in rat liver", (1990) Biochem. J. 270, 815-820 M. Trinchera, B. Pirovano and R. Ghidoni, "Sub-Golgi distribution
in rat liver of CMP-NeuAc: GM3- and CMP-NeuAc: GT1b a2-8sialyltransferases and
comparison with the distribution of the other glycosyltransferase activities
involved in ganglioside biosynthesis", (1990) J. Biol. Chem. 265,
18242-18247 M. Trinchera, A. Fiorilli and R. Ghidoni, "Localization in the
Golgi apparatus of rat liver UDP-Gal: glucosylceramide b1-4galactosyltransferase",
(1991) Biochemistry 30, 2719-2724 M. Trinchera, D. Carrettoni and R. Ghidoni,
"A part of glucosylceramide formed from exogenous lactosylceramide is not
degraded to ceramide but re-cycled and glycosylated in the Golgi
apparatus", (1991) J. Biol. Chem. 266, 9093-9099 M. Trinchera, M. Fabbri and R. Ghidoni, "Topography of
glycosyltransferases involved in the initial glycosylations of
gangliosides", (1991) J. Biol. Chem. 266, 20907-20912 M. Gersten, S. Natsuka, M. Trinchera, B. Petryniac, R. J. Kelly, N.
Hiraiwa, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and J. B. Lowe,
"Molecular cloning, expression, chromosomal assignment, and
tissue-specific expression of a murine a-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1
ligand fucosyl transferase", (1995) J. Biol. Chem. 270, 25047-25056 M. Trinchera, and S. Bozzaro, “Dictyostelium cytosolic
fucosyltransferase synthesizes H type I trisaccharide in vitro”, (1996)
FEBS Lett. 395, 68-72 M. Valli, A. Gallanti, S. Bozzaro, and M.
Trinchera, “b1,3-galactosyltransferase and a1,2-fucosyltransferase involved in the biosynthesis of type 1 chain
carbohydrate antigens in human adenocarcinoma cell lines”, (1998) Eur. J.
Biochem. 256, 494-501. M. Valli, A. Bardoni, and M. Trinchera, “Mouse C127 cells
transfected with fucosyltransferase Fuc-TIII express masked Lexis x but not
Lewis x antigen”, (1999) Glycobiology 9, 83-91. A. Bardoni, M. Valli, and M. Trinchera “Differential
expression of b1,3galactosyltransferases in human colon cells derived from
adenoarcinomas or normal mucosa”, (1999) FEBS Lett. 451, 75-80. R. Salvini, A. Bardoni, M. Valli and M. Trinchera “b1,3-galactosyltransferase b3Gal-T5 acts on the GlcNAcb1-3Galb1-4GlcNAcb1-R sugar chains of
carcinoembryonic antigen and other N-linked glycoproteins, and is
down-regulated in colon adenocarcinomas”, (2001) J. Biol. Chem. 276,
3564-3573. L. Mare and M. Trinchera, “Suppression of b1,3 galactosyltransferase b3Gal-T5 in cancer cells
reduces sialyl-Lewis a and enhances poly-N-acetyllactosamines and sialyl-Lewis
x on O-glycans” , (2004) Eur. J. Biochem. 271, 186-194 |
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