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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Francesco Lo Curto
The University of Insubria CV
 

Contact data

Full Professor of Human Genetics
Department of Experimental and Clinical Biomedical Sciences
Via J. H. Dunant, 5
21100 Varese Italy
Tel: ++39 0332 217184
Fax: ++39 0332 217119
E-mail: francesco.locurto@uninsubria.it
 

Biography

 Born on June 25th, 1943.
Graduated in Biological Sciences in 1969.

Assistant Professor at the University of Pavia, Inst. General Biology and Medical Genetics, 1970-1979.

Full Professor of General Biology, Medical Faculty, University of Naples, 1979-1980

Full Professor of Human Genetics, Medical Faculty, University of Pavia, 1981-1998.

Since the foundation of the University of Insubria, July 14th, 1998, Full Professor of Human Genetics, Medical FacultySchool of Medicine , University of Insubria.
 

Qualifications and awards

 Member of the Italian Association of Human Cytogenetics. Member of the Italian Association of Medical Genetics. Member of the Italian Society of Human Genetics.
 

Research interests

 Research in different fields of Human and Medical Genetics, mainly in Human Cytogenetics. Studies on cell culture methodologies, on karyotype/phenotype correlations in patients with constitutional chromosome anomalies, on acquired chromosome changes in neoplasms, on the cytogenetic characterization of cell lines, both non-human and human, derived from normal and neoplastic tissues. Research interests of the last years included molecular cytogenetic studies on cholesteatoma, and on monosomy 7 and trisomy 8 in myeloid malignancies. The preferential parental origin of the chromosomes involved in anomalies in neoplasms was investigated with molecular genetics methods. More recent work is concerned with the three following points:

- Mutator effects acting through chromosome changes in Myelodysplasia (MDS) and Acute Myeloid Leukaemia (AML), with studies on Mendelian predisposing conditions, such as FPD/AML (Familial platelet disorder with propension to AML/MDS – OMIM 601399), Shwachman syndrome, Rothmund-Thomson syndrome, Noonan syndrome, and on familial cases of MDS/AML;

- Mechanisms of origin of structural chromosome changes in AML/MDS;

- Mechanisms of origin of numerical chromosome changes in AML/MDS.
 

Teaching experience and appointments

 The teaching experience includes:
- Courses of General Biology in the Course for the degree in Medicine e Surgery, since 1974, at the Universities of Naples, Pavia, and Insubria;
- Courses of General Biology in the Course for the degree in Dentistry, since 2001, at the University of Insubria;
- Courses of Human and Medical Genetics in many different Postgraduate Schools of Specialization (such as General Medicine, Pediatrics, Obstetrics, Pediatric Neuropsychiatry, Psychiatry, Neurology etc.).
-Head of the Department of Human and Hereditary Pathology, University of Pavia, 1981-1988.
-Head of the Postgraduate School of Specialization in Medical Genetics, since 2004.
 

Representative  publications

 1 – Lo Curto F, Scappaticci S, Fraccaro M: Chromosome identification in a Chinese hamster pseudodiploid cell line (CHEF – 125). Cytogenetics 11:305–312, 1972.

2 – Lo Curto F, Scappaticci S, Zuffardi O, Chierichetti G, Fraccaro M: Non-fluorescent Y chromosome in a 45, X / 46, XY mosaic. Ann Gènèt 15:107-110, 1972.

3 – Scappaticci S, Lo Curto F, Mira E: Karyotypic variation in benign pleomorphic adenoma of the parotid and normal salivary glands. Acta Otolaring 76:221-228, 1973.

4 – Lo Curto F, Fraccaro M: Nuclear projections in tumour cells. Lancet ii:847, 1974.

5 – Lo Curto F, Pucci E, Scappaticci S, Scotta S, Severi F, Burgio GR, Fraccaro M: X0 and male phenotype. J Dis Child 128:90-91, 1974.

6 – Lo Curto F, Castello A, Magrini U, Nappi G: Cytochemistry of cultured fibroblasts in myotonic dystrophy. J Genet Hum 25:173-178, 1975.

7 – Lo Curto F, Maraschio P, Milanesi P, Severi F, Ugazio AC, Zuffardi O: The syndrome of partial trisomy 14q. Europ J Ped 123:237-241, 1976.

8 – Simoni G, Montali E, Rossella F, Dalprà L, Lo Curto F: A women carrier of two apparently unrelated reciprocal translocations: prenatal diagnosis of natural karyotype in the foetus. Hum Genet 46:159-162, 1979.

9 – Maraschio P, Zuffardi O, Lo Curto F: Cd bands and centromeric function in dicentric chromosomes. Hum Genet 54:265-267, 1980.

10 – Fraccaro M, Mayerova A, Wolf U, Buhler E, Gebauer J, Gilgenkrantz S, Lindsten J, Lo Curto F, Ritzèn: Correlation between the number of sex chromosomes and the H-Y antigen titer. Hum Genet 61:135-140, 1982.

11 – Zuffardi O, Maraschio P, Lo Curto F, Muller U, Giarola A, Poloni L: The role of Yp in sex determination: new evidence from X / Y translocations. Am J Med Genet 12:175-184, 1982.

12 – Danesino C, Lo Curto F, Bonfant G, Cazzadore C, Voltolin, Bersi S: Deficiency 10p. Report of a case and exclusion mapping of the Hexokinase 1 locus to band 10p11.2. Ann Gènèt 27:162-166, 1984.

13 – Maraschio P, Danesino C, Lo Curto F, Zuffardi O, Dalla Fior T, Pedrotti D: A liveborn 69,XXX triploid. Origin, chromosome activity and gene dosage. Ann Gènèt 27:96-101, 1984.

14 – Peretti D, Maraschio P, Lambiase S, Lo Curto F, Zuffardi O: Indirect immunofluorescence of inactive centromeres as indicator of centromeric function . Hum Genet 73:12–16, 1986.

15 – Maraschio P, Peretti D, Lambiase S, Lo Curto F, Caufin D, Gargantini l, Minoli L, Zuffardi O: A new chromosome instability disorder. Clin Genet 30:353-365, 1986.

16 – Zuffardi O, Gargantini L, Limbiase S, Lo Curto F, Maraschio P, Ford CE: Presumptive mosaic origin of an XX/XY female with ambiguous genitalia. J Med Genet 24:177-180, 1987.

17 – Fraccaro M, Lindsten J, Lo Curto F: The origin and phenotype of X0 males. Hum Genet 75:392, 1987.

18 – Minelli A, Danesino C, Lo Curto F, Tenti P, Zampatti C, Simone G, Rossella F, Fois A: First trimester prenatal diagnosis of Sanfilippo disease (MPS III) typo B. Prenat Diagn 8:47-52, 1988.

19 – Piccolo G, Aschei M, Ricordi A, Banfi P, Lo Curto F, Fratino P: Normal insukin receptors in mitochondrial myopathies with ophalmoplegia. J Neurol Sci 94:163-172, 1989.

20 – Bocchini V, Casalone R, Collini P, Rebel G, Lo Curto F: Glial fibrillare acidic protein expression and chromosomal findings of two human glioblastoma cell lines in continuous culture: Cell Tissue Res 265:73-81,1991.

21 – Barreca A, Larizza D, Damante G, Arvigo M, Ponzani P, Cesarone A, Lo Curto F, Severi F, Giordano G, Minuto F : Insulin-like growth factors (IGF-I and IGF-II) and IGF- binding protein-3 production by fibroblasts of patients with Turner’s syndrome in culture. J Clin Endocr Metab 82:1041-1046, 1997.

22 – Seghezzi L, Dellavecchia C, Maserati E, Minelli A, Carra’ A, Locatelli F, Argusti A, Lo Curto F, Danesino C, Pasquali F: Ph-Positive CML in Blastic Phase with Monosomy 7 in a Down Syndrome Patient. Cancer Genetic Cytogenet 99:77-80, 1997.

23 – Minelli A, Maserati E, Giudici G, Tosi S, Olivieri C, Bonvini L, De Filippi P, Biondi A, Lo Curto F, Pasquali F, Danesino C: Familial partial monosomy 7 and myelodysplasia: different paternal origin of the monosomy 7 suggests action of a mutator gene. Cancer Genet Cytogenet 124:147-151, 2001.

24 – Maserati E, Aprili F, Vinante F, Locatelli F, Amendola G, Zatterale A, Milone G, Minelli A, Bernardi F, Lo Curto F, Pasquali F: Trisomy 8 in myelodysplasia and acute leukemia is constitutional in 15-20% of cases. Genes Chromosom Cancer 33:93-97, 2002.

25 – Maserati E, Minelli A, Menna G, Cecchini MP, Bernardo ME, Rossi G, De Filippi P, Lo Curto F, Danesino C, Locatelli F, Pasquali F: Familial myelodysplastic syndromes, monosomy 7/trisomy 8, and mutator effects. Cancer Genet Cytogenet 148:155-158, 2004.

26 – Minelli A, Maserati E, Rossi G, Bernardo ME, De Stefano P, Cecchini MP, Valli R, Albano V, Pierani P, Leszl A, Sainati L, Lo Curto F, Danesino C, Locatelli F, Pasquali F: Familial platelet disorder with propensity to acute myelogenous leukemia: genetic heterogeneity and progression to leukemia via acquisition of clonal chromosome anomalies. Genes Chromosom Cancer 40:165-171, 2004.

27 – Mattarucchi E, Marsoni M, Binelli G, Passi A, Lo Curto F, Pasquali F, Porta G: Different real time PCR approaches for the fine quantification of SNP’s alleles in DNA pools: assays development, characterization and pre-validation. J Biochem Mol Biol 38:555-562, 2005.

28 – Maserati E, Minelli A, Pressato B, Valli R, Crescenzi B, Stefanelli M, Menna G, Sainati L, Poli F, Panarello C, Zecca M, Lo Curto F, Mecucci C, Danesino C, Pasquali F: Shwachman sindrome as mutator phenotype responsible for myeloid displasia/neoplasia through karyotype instability and chromosomes 7 and 20 anomalies. Genes Chromosom Cancer, in press.
 

Clinical interests

Diagnostic procedures of constitutional and acquired chromosome anomalies in man.

 
 
   
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