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Contact data |
Full Professor
of Biochemistry
Department of Experimental and Clinical Biomedical Sciences
Via Dunant 5, 21100 Varese.
Tel: 0332 397140
Fax: 0332 397119
E-mail: giancarlo.deluca@uninsubria.it |
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Biography |
Born in Milan, November
25, 1947
Degree in Medicine and Surgery, University of Pavia, 6.7.1972, 110/110
cum laude.
Post-doctoral degree of Specialization in Biological Chemistry,
Faculty of Sciences, University of Pavia, 4.12.1975, 50/50 cum laude.
Post-doctoral degree of Specialization in Clinical Analysis, Faculty
of Medicine and Surgery, University of Pavia, 18.11.1977, 50/50
cum laude.
Temporary Professor of Biochemistry, Faculty of Medicine and Surgery,
University of Pavia, from 1.11.1976 till 3.2.1983.
Associate Professor of Biochemistry, Faculty of Medicine and Surgery,
University of Pavia, from 3.2.1983 till 17.7.1986.
Full Professor of Biochemistry, Faculty of Sciences, University
of Sassari, from 18.7.1986 till 31.10.1989.
Head of the Institute
of Applied Biology, University of Sassari, from 10.9.1986 till 31.10.1989.
Full Professor of Biochemistry, Faculty of Medicine and Surgery,
University of Pavia, from 1.11.1989 till 31.10.1990.
Full Professor of Biochemistry, 2nd Faculty of Medicine and Surgery
(located in Varese), University of Pavia, from 1.11.1990 till 13.7.1998.
Full Professor of Biochemistry, School of Medicine at the University of Insubria (Varese), from 14.7.1998.
Head physician of the Clinical Chemistry Laboratory of “Ospedale
di Circolo” (Varese) from 1.10.2004.
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Qualifications and awards |
Official Reviewer of MIUR
for research projects of national interest in the field of Biological
Sciences (8 national projects reviewed in 2003-2004).
Official Reviewer of CIVR for research products of Universities.
Founder Fellow of Italian Connective Tissue Society.
Member of Italian Society of Biochemistry and Molecular Biology.
Head of the “Glycoconjugate” Group of Italian Biochemical
Society from 4.10.1988 till 31.12.1992.
Member of the Managing Board of Italian Society of Biochemistry and
Molecular Biology from 2004.
Member of the Managing Board of Italian Histochemical Society from
20.9.1989 till 31.12.1993. |
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Research interests |
1-Regulation of glycosaminoglycan
biosynthesis.
2-Modifications of proteoglycans with aging and cellular senescence.
3-Modifications of collagen and proteoglycans in pathological
conditions
affecting connective tissues.
4-The role of proteoglycans and glycosaminoglycans in atherosclerosis
and in lipid peroxidation.
5-The involvement of proteoglycans and glycosaminoglycans in lung
edema. |
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Teaching experience and appointments |
30 years of teaching experience
was acquired in the field of Biochemistry, including both the general
aspects and the topics dealing with cell and tissue Biochemistry.
Temporary Professor of Biochemistry, Faculty of Medicine and Surgery,
University of Pavia, from 1.11.1976 till 3.2.1983.
Associate Professor of Biochemistry, Faculty of Medicine and Surgery,
University of Pavia, from 3.2.1983 till 17.7.1986.
Full Professor of Biochemistry, Faculty of Sciences, University of
Sassari, from 18.7.1986 till 31.10.1989.
Full Professor of Biochemistry, Faculty of Medicine and Surgery, University
of Pavia, from 1.11.1989 till 31.10.1990.
Full Professor of Biochemistry, 2nd School of Medicine at the University of Insubria
(Varese), University of Pavia, from 1.11.1990 till 13.7.1998.
Full Professor of Biochemistry, School of Medicine at the University of Insubria (Varese), from 14.7.1998.
At present, in the University of Insubria he is:
Rectorial Delegate for building trade, Member of the University Senate, Director of the School of Specialization in Clinical Biochemistry, President of the course for the degree in Techniques of
Biomedical
Laboratory, Coordinator of the Doctorate in Biotecnology,
President of the Scientific Committee of the Service Centre managing
the instruments for Biomedical Research. |
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Representative publications |
1. Modifications of proteoglycans
secreted into the growth medium by young and senescent human skin
fibroblasts.
Passi A., Albertini R., Campagnari F., De Luca G.
FEBS Lett. (1997) 402,286-290.
2. Chondroitin 4-sulphate exhibits inhibitory effect during Cu2+-mediated
LDL oxidation. Albertini R., Ramos P., GiessaufA., Passi A., De Luca
G., Esterbauer H.
FEBS Lett. (1997) 403, 154-158.
3. Modifications of proteoglycans extracted from monolayer cultures
of young and senescent human skin fibroblasts.
Passi A., Albertini R., Campagnari F., De Luca G.
FEBS Lett. (1997) 420, 175-178.
4. Proteoglycan involvement during development of lesional pulmonary
edema. Negrini D., Passi A., De Luca G., Miserocchi G.
Am.J.Physiol. (1998) (Lung Cell.Mol.Physiol. 18) 274, L203-L211.
5. Involvement of lung interstitial proteoglycans in development of
hydraulic- and elastase-induced edema.
Passi A., Negrini D., Albertini R., De Luca G., Miserocchi G.
Am.J.Physiol. (1998) (Lung Cell.Mol.Physiol. 19) 275, L631-L635.
6. Role of matrix macromolecules in controlling lung f/uid balance:
transition from a dry tissue to edema.
Negrini D., Passi A., De Luca G., Miserocchi G.
In "Acute respiratory distress syndrome: cellular and molecular
mechanisms and clinical management", Matalon S., Szneyder J.I.
eds., Plenum Press, New York, 1998, pp. 65-68.
7. A new function of chondroitinsulphate: the protective role against
Cu2+ -mediated oxidation of LDL and HDL.
Albertini R., Abuja P., Passi A., De Luca G.
In "European training program in microseparation techniques",
(ECOSEP 1 ), Karamanos N. ed., University of Patras, 1998, pp.415-425.
8. Proteoglycans in pulmonary edema.
Passi A., Albertini R., De Luca G., Miserocchi G., Negrini D.
In "European training program in microseparation techniques",
(ECOSEP 1 ), Karamanos N. ed., University of Patras, 1998, pp.426-440.
9. Chondroitin-4-sulphate protects high-density lipoprotein against
copper-dependent oxidation.
Albertini R., De Luca G., Passi A., Moratti R., Abuja P.
Arch.Biochem.Biophys. (1999) 365, 143-149.
10. The sensitivity of versican from rabbit lung to gelatinase A (MMP-2)
and B (MMP-9) and its involvement in the development of hydraulic
edema.
Passi A., Negrini D., Albertini R., Miserocchi G., De Luca G.
FEBS Lett. (1999) 456, 93-96.
11. Mechanistic aspects of the relationship between low-Ievel chemiluminescence
and lipid peroxides in oxidation of low-density lipoprotein.
Albertini R., De Luca G., Palladini G., Passi A., Melzi d'Eril G.,
Abuja P.M.
FEBS Lett. (1999) 459,47-50.
12. Interstitial pressure and proteoglycan degradation in hydraulic-
and elastase-induced lung edema.
Giuseppe Miserocchi, Alberto Passi, Riccardo Albertini, Daniela Negrini,
Giancarlo De Luca.
Chest (1999) 116,31.
13. The effect of glycosaminoglycans and proteoglycans on lipid peroxidation
(Review). Riccardo Albertini, Alberto Passi, Peter M. Abuja, Giancarlo
De Luca.
Int.J.Mol.Med. (2000) 6, 129-136.(Review).
14. Development of lung edema: interstitial fluid dynamics and molecular
structure.
Giuseppe Miserocchi, Daniela Negrini, Alberto Passi, Giancarlo De
Luca.
News Physiol.Sci. (2001) 16, 66-71.
15. Pulmonary interstitial pressure and tissue matrix structure in
acute hypoxia.
Giuseppe Miserocchi, Alberto Passi, Daniela Negrini, Massimo Dal Fabbro,
Giancarlo De Luca.
Amer.J.Physiol. (2001)(Lung Cell.Mol.Physiol.) 280, L881-L887.
16. Matrix proteoglycans in development of pulmonary edema.
Daniela Negrini, Giancarlo De Luca, Alberto Passi, Giuseppe Miserocchi.
In: Proteoglycans in lung disease. Ed. by HG Garg, P.J. Roughley and
C.A.Hales. Marcel Dekker , Inc. (2002), pp.143-168.
17. Glucose accelerates copper-and ceruloplasmin-induced oxidation
of low-density lipoprotein and whole serum.
Valerio Leoni, Riccardo Albertini, Alberto Passi, Peter M. Abuja,
Pierangelo Borroni, Gianvico Melzi d’Eril, Giancarlo De Luca.
Free Radical Res. (2002) 36, 521-529.
18. Compositional and structural alterations of chondroitin and dermatan
sulphates during the progression of atherosclerosis and aneurismal
dilation of human abdominal aorta.
Achilleas D. Theocharis, Dimitrios A. Theocharis, Giancarlo De Luca,
Anders Hjerpe, Nikos K. Karamanos.
Biochimie (2002) 84, 667-674.
19. Oxidation of low-density lipoprotein in athrosclerosis from basis
biochemistry toclinical studies.
R. Albertini, R. Moratti, G. De Luca.
Curr.Mol.Med. (2002) 2, 581-594.
20. Changes in human plasma levels of the brain specific oxysterol
24S-hydroxycholesterol during progression of multiple sclerosis.
V. Leoni, T. Masterman, U. Diczfalusy, G. De Luca, J. Hillert, I.Bjorkhem.
Neurosci. Lett. (2002) 331, 163-166.
21. Molecular cloning, genomic organization and developmental expression
of the Xenopus laevis hyaluronan synthase 3.
D. Vigetti, M. Viola, R. Gornati, M. Ori, I. Nardi, A. Passi, G. De
Luca, G. Bernardini.
Matrix Biology (2003) 22, 511-517.
22 Analysis of fluorophore-labelled hyaluronan and chondroitin sulphate
disaccharides in biological compounds.
J. Karousou, G. Porta, G. De Luca, A. Passi.
J.Pharmac.Bioch.Anal. (2004) 34, 791-795.
23. Polyacrilamide gel electrophoresis of fluorophore-labeled hyaluronan
and chondroitin sulfate disaccharides: Application to the analysis
in cells and tissues.
E.G. Karousou, M. Militsopoulou, G. Porta, G. De Luca, V.C. Hascall,
A. Passi
Electrophoresis (2004) 25, 2919-2925.
24. Hyaluronan content of umbilical cords of healthy and Down Syndrome
fetuses.
A. Passi, L Raio, E. Cereda, F. Ghezzi, F. Pallotti, G. Porta, A.
Cromi, P. Bolis, G. De Luca.
In Hyaluronan 2003 Proceedings , Matrix biology Institute, A.Balasz
and VC Hascall eds, cap. 8, (2004), in press; electronic copy: www.matrixbiologyinstitute.org/ha03/ch8/index.htm
25. Hyaluronan in Xenopus laevis development
D. Vigetti, M. Viola, E. Cereda, R. Gornati, E. Karousou, M. Ori,
I. Nardi, G. Bernardini, A. Passi, G. De Luca.
In Hyaluronan 2003 Proceedings , Matrix biology Institute, A.Balasz
and VC Hascall eds, cap 2, (2004), in press electronic copy: www.matrixbiologyinstitute.org/ha03/ch2/index.htm
26. Hyaluronan content of Wharton´s jelly in healthy and Down
syndrome fetuses.
L. Raio, A. Cromi, F. Ghezzi, A. Passi, E. Karousou, M. Viola, D.
Vigetti, G. De Luca, P. Bolis.
Matrix Biology (2005) 24, 166-175.
27. Application of polyacrylamide gel electrophoresis of fluorophore
labelled-saccharides for analysis of hyaluronan and chondroitin sulfate
in human and animal tissues and cell cultures.
E. Karousou, M. Viola, A. Genasetti, D. Vigetti, G. De Luca, N. Karamanos,
A. Passi.
Biomedical Chromatography (2005), in press.
28. Dermal fibroblasts from Pseudoxanthoma elasticum patients have
raised MMP-2 degradative potential.
D. Quaglino; L. Sartor; S. Garbisa; F. Boraldi; A. Croce; A. Passi;
G. De Luca; R. Tiozzo; I. Pasquali Ronchetti.
Biochim. Biophys. Acta - Molecular Basis of Disease (2005) 1741, 42-47.
29. C-reactive protein production in term human placental tissue.
Malek A., Bersinger N.A., Di Santo S., Mueller M.D., Sager R., Schneider
H., Grezzi F., Karousou E., Passi A., De Luca G., Raio L.
Placenta (2005) in press.
30. Decorin from different bovine tissues: studies of glycosaminoglycan
chain by PAGEFS.
M. Viola, E.G. Karousou, D. Vigetti, A. Genasetti, F. Pallotti, G.F.
Guidetti, E. Tira, G. De Luca, A. Passi.
J.Pharmac.Bioch.Anal. (2005) in press. |
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Clinical interests |
Diseases affecting connective
tissues and, in particular, the molecular organization of extracellular
matrix. |
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