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The University of Insubria
The Univsersity of Insubria

 
The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Giancarlo De Luca
The University of Insubria CV
 

Contact data

Full Professor of Biochemistry
Department of Experimental and Clinical Biomedical Sciences
Via Dunant 5, 21100 Varese.
Tel: 0332 397140
Fax: 0332 397119
E-mail: giancarlo.deluca@uninsubria.it

 

Biography

Born in Milan, November 25, 1947

Degree in Medicine and Surgery, University of Pavia, 6.7.1972, 110/110 cum laude.

Post-doctoral degree of Specialization in Biological Chemistry, Faculty of Sciences, University of Pavia, 4.12.1975, 50/50 cum laude.
Post-doctoral degree of Specialization in Clinical Analysis, Faculty of Medicine and Surgery, University of Pavia, 18.11.1977, 50/50 cum laude.

Temporary Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 1.11.1976 till 3.2.1983.

Associate Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 3.2.1983 till 17.7.1986.

Full Professor of Biochemistry, Faculty of Sciences, University of Sassari, from 18.7.1986 till 31.10.1989.

Head of the Institute of Applied Biology, University of Sassari, from 10.9.1986 till 31.10.1989.

Full Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 1.11.1989 till 31.10.1990.

Full Professor of Biochemistry, 2nd Faculty of Medicine and Surgery (located in Varese), University of Pavia, from 1.11.1990 till 13.7.1998.

Full Professor of Biochemistry, School of Medicine at the University of Insubria (Varese), from 14.7.1998.

Head physician of the Clinical Chemistry Laboratory of “Ospedale di Circolo” (Varese) from 1.10.2004.

 

Qualifications and awards

Official Reviewer of MIUR for research projects of national interest in the field of Biological Sciences (8 national projects reviewed in 2003-2004).

Official Reviewer of CIVR for research products of Universities.
Founder Fellow of Italian Connective Tissue Society.

Member of Italian Society of Biochemistry and Molecular Biology.

Head of the “Glycoconjugate” Group of Italian Biochemical Society from 4.10.1988 till 31.12.1992.

Member of the Managing Board of Italian Society of Biochemistry and Molecular Biology from 2004.

Member of the Managing Board of Italian Histochemical Society from 20.9.1989 till 31.12.1993.
 

Research interests

1-Regulation of glycosaminoglycan biosynthesis.

2-Modifications of proteoglycans with aging and cellular senescence.

3-Modifications of collagen and proteoglycans in pathological
conditions affecting connective tissues.

4-The role of proteoglycans and glycosaminoglycans in atherosclerosis and in lipid peroxidation.

5-The involvement of proteoglycans and glycosaminoglycans in lung edema.
 

Teaching experience and appointments

30 years of teaching experience was acquired in the field of Biochemistry, including both the general aspects and the topics dealing with cell and tissue Biochemistry.

Temporary Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 1.11.1976 till 3.2.1983.

Associate Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 3.2.1983 till 17.7.1986.

Full Professor of Biochemistry, Faculty of Sciences, University of Sassari, from 18.7.1986 till 31.10.1989.

Full Professor of Biochemistry, Faculty of Medicine and Surgery, University of Pavia, from 1.11.1989 till 31.10.1990.

Full Professor of Biochemistry, 2nd School of Medicine at the University of Insubria (Varese), University of Pavia, from 1.11.1990 till 13.7.1998.

Full Professor of Biochemistry, School of Medicine at the University of Insubria (Varese), from 14.7.1998.

At present, in the University of Insubria he is:

Rectorial Delegate for building trade, Member of the University Senate, Director of the School of Specialization in Clinical Biochemistry, President of the course for the degree in Techniques of

Biomedical Laboratory, Coordinator of the Doctorate in Biotecnology,
President of the Scientific Committee of the Service Centre managing the instruments for Biomedical Research.

 

Representative  publications

1. Modifications of proteoglycans secreted into the growth medium by young and senescent human skin fibroblasts.
Passi A., Albertini R., Campagnari F., De Luca G.
FEBS Lett. (1997) 402,286-290.

2. Chondroitin 4-sulphate exhibits inhibitory effect during Cu2+-mediated LDL oxidation. Albertini R., Ramos P., GiessaufA., Passi A., De Luca G., Esterbauer H.
FEBS Lett. (1997) 403, 154-158.

3. Modifications of proteoglycans extracted from monolayer cultures of young and senescent human skin fibroblasts.
Passi A., Albertini R., Campagnari F., De Luca G.
FEBS Lett. (1997) 420, 175-178.

4. Proteoglycan involvement during development of lesional pulmonary edema. Negrini D., Passi A., De Luca G., Miserocchi G.
Am.J.Physiol. (1998) (Lung Cell.Mol.Physiol. 18) 274, L203-L211.

5. Involvement of lung interstitial proteoglycans in development of hydraulic- and elastase-induced edema.
Passi A., Negrini D., Albertini R., De Luca G., Miserocchi G.
Am.J.Physiol. (1998) (Lung Cell.Mol.Physiol. 19) 275, L631-L635.

6. Role of matrix macromolecules in controlling lung f/uid balance: transition from a dry tissue to edema.
Negrini D., Passi A., De Luca G., Miserocchi G.
In "Acute respiratory distress syndrome: cellular and molecular mechanisms and clinical management", Matalon S., Szneyder J.I. eds., Plenum Press, New York, 1998, pp. 65-68.

7. A new function of chondroitinsulphate: the protective role against Cu2+ -mediated oxidation of LDL and HDL.
Albertini R., Abuja P., Passi A., De Luca G.
In "European training program in microseparation techniques", (ECOSEP 1 ), Karamanos N. ed., University of Patras, 1998, pp.415-425.

8. Proteoglycans in pulmonary edema.
Passi A., Albertini R., De Luca G., Miserocchi G., Negrini D.
In "European training program in microseparation techniques", (ECOSEP 1 ), Karamanos N. ed., University of Patras, 1998, pp.426-440.

9. Chondroitin-4-sulphate protects high-density lipoprotein against copper-dependent oxidation.
Albertini R., De Luca G., Passi A., Moratti R., Abuja P.
Arch.Biochem.Biophys. (1999) 365, 143-149.

10. The sensitivity of versican from rabbit lung to gelatinase A (MMP-2) and B (MMP-9) and its involvement in the development of hydraulic edema.
Passi A., Negrini D., Albertini R., Miserocchi G., De Luca G.
FEBS Lett. (1999) 456, 93-96.

11. Mechanistic aspects of the relationship between low-Ievel chemiluminescence and lipid peroxides in oxidation of low-density lipoprotein.
Albertini R., De Luca G., Palladini G., Passi A., Melzi d'Eril G., Abuja P.M.
FEBS Lett. (1999) 459,47-50.

12. Interstitial pressure and proteoglycan degradation in hydraulic- and elastase-induced lung edema.
Giuseppe Miserocchi, Alberto Passi, Riccardo Albertini, Daniela Negrini, Giancarlo De Luca.
Chest (1999) 116,31.

13. The effect of glycosaminoglycans and proteoglycans on lipid peroxidation (Review). Riccardo Albertini, Alberto Passi, Peter M. Abuja, Giancarlo De Luca.
Int.J.Mol.Med. (2000) 6, 129-136.(Review).

14. Development of lung edema: interstitial fluid dynamics and molecular structure.
Giuseppe Miserocchi, Daniela Negrini, Alberto Passi, Giancarlo De Luca.
News Physiol.Sci. (2001) 16, 66-71.

15. Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia.
Giuseppe Miserocchi, Alberto Passi, Daniela Negrini, Massimo Dal Fabbro, Giancarlo De Luca.
Amer.J.Physiol. (2001)(Lung Cell.Mol.Physiol.) 280, L881-L887.

16. Matrix proteoglycans in development of pulmonary edema.
Daniela Negrini, Giancarlo De Luca, Alberto Passi, Giuseppe Miserocchi.
In: Proteoglycans in lung disease. Ed. by HG Garg, P.J. Roughley and C.A.Hales. Marcel Dekker , Inc. (2002), pp.143-168.

17. Glucose accelerates copper-and ceruloplasmin-induced oxidation of low-density lipoprotein and whole serum.
Valerio Leoni, Riccardo Albertini, Alberto Passi, Peter M. Abuja, Pierangelo Borroni, Gianvico Melzi d’Eril, Giancarlo De Luca.
Free Radical Res. (2002) 36, 521-529.

18. Compositional and structural alterations of chondroitin and dermatan sulphates during the progression of atherosclerosis and aneurismal dilation of human abdominal aorta.
Achilleas D. Theocharis, Dimitrios A. Theocharis, Giancarlo De Luca, Anders Hjerpe, Nikos K. Karamanos.
Biochimie (2002) 84, 667-674.

19. Oxidation of low-density lipoprotein in athrosclerosis from basis biochemistry toclinical studies.
R. Albertini, R. Moratti, G. De Luca.
Curr.Mol.Med. (2002) 2, 581-594.

20. Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis.
V. Leoni, T. Masterman, U. Diczfalusy, G. De Luca, J. Hillert, I.Bjorkhem.
Neurosci. Lett. (2002) 331, 163-166.

21. Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3.
D. Vigetti, M. Viola, R. Gornati, M. Ori, I. Nardi, A. Passi, G. De Luca, G. Bernardini.
Matrix Biology (2003) 22, 511-517.

22 Analysis of fluorophore-labelled hyaluronan and chondroitin sulphate disaccharides in biological compounds.
J. Karousou, G. Porta, G. De Luca, A. Passi.
J.Pharmac.Bioch.Anal. (2004) 34, 791-795.

23. Polyacrilamide gel electrophoresis of fluorophore-labeled hyaluronan and chondroitin sulfate disaccharides: Application to the analysis in cells and tissues.
E.G. Karousou, M. Militsopoulou, G. Porta, G. De Luca, V.C. Hascall, A. Passi
Electrophoresis (2004) 25, 2919-2925.

24. Hyaluronan content of umbilical cords of healthy and Down Syndrome fetuses.
A. Passi, L Raio, E. Cereda, F. Ghezzi, F. Pallotti, G. Porta, A. Cromi, P. Bolis, G. De Luca.
In Hyaluronan 2003 Proceedings , Matrix biology Institute, A.Balasz and VC Hascall eds, cap. 8, (2004), in press; electronic copy: www.matrixbiologyinstitute.org/ha03/ch8/index.htm

25. Hyaluronan in Xenopus laevis development
D. Vigetti, M. Viola, E. Cereda, R. Gornati, E. Karousou, M. Ori, I. Nardi, G. Bernardini, A. Passi, G. De Luca.
In Hyaluronan 2003 Proceedings , Matrix biology Institute, A.Balasz and VC Hascall eds, cap 2, (2004), in press electronic copy: www.matrixbiologyinstitute.org/ha03/ch2/index.htm

26. Hyaluronan content of Wharton´s jelly in healthy and Down syndrome fetuses.
L. Raio, A. Cromi, F. Ghezzi, A. Passi, E. Karousou, M. Viola, D. Vigetti, G. De Luca, P. Bolis.
Matrix Biology (2005) 24, 166-175.

27. Application of polyacrylamide gel electrophoresis of fluorophore labelled-saccharides for analysis of hyaluronan and chondroitin sulfate in human and animal tissues and cell cultures.
E. Karousou, M. Viola, A. Genasetti, D. Vigetti, G. De Luca, N. Karamanos, A. Passi.
Biomedical Chromatography (2005), in press.

28. Dermal fibroblasts from Pseudoxanthoma elasticum patients have raised MMP-2 degradative potential.
D. Quaglino; L. Sartor; S. Garbisa; F. Boraldi; A. Croce; A. Passi; G. De Luca; R. Tiozzo; I. Pasquali Ronchetti.
Biochim. Biophys. Acta - Molecular Basis of Disease (2005) 1741, 42-47.

29. C-reactive protein production in term human placental tissue.
Malek A., Bersinger N.A., Di Santo S., Mueller M.D., Sager R., Schneider H., Grezzi F., Karousou E., Passi A., De Luca G., Raio L.
Placenta (2005) in press.

30. Decorin from different bovine tissues: studies of glycosaminoglycan chain by PAGEFS.
M. Viola, E.G. Karousou, D. Vigetti, A. Genasetti, F. Pallotti, G.F. Guidetti, E. Tira, G. De Luca, A. Passi.
J.Pharmac.Bioch.Anal. (2005) in press.
 

Clinical interests

Diseases affecting connective tissues and, in particular, the molecular organization of extracellular matrix.
 
   
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