The University of Insubria

		Luigina Guasti

	Contact data	Associate Professor Department of Clinical Medicine c/o Ospedale di Circolo, Division of Internal Medicine Viale Borri, 57 - 21100 Varese - Italy Tel: +39 (0)332 278828 Fax: +39 (0)332 278595 E-mail: luigina.guasti@uninsubria.it
	Biography	Place and date of birth: Piacenza, November 3, 1958 Present position: Associate Professor of Internal Medicine, University of Insubria Assistant, Department of Medicine of the University Hospital, Division of Internal Medicine I, Azienda Ospedaliera-Universitaria, Ospedale di Circolo, Varese Education: Maturità Scientifica, Liceo Scientifico Respighi, Piacenza, MD Degree (Magna cum laude), University of Pavia, 1983 ECFMG (Educational Commission Foreign Medical Graduates) Certification 1985, after FMGEMS (Foreign Medical Graduate Examination in Medical Sciences), and TOEFL (Test of English as a Foreign Language) Speciality Degree, University of Pavia, Post Doctoral School of Cardiology, 1987 PhD in Cardiovascular Physiopathology, University of Pavia, 1994 Research training: Visiting Fellow: Varsaw, Poland, August 1980 Dublin, Irland, September1982 Rochester, MN, USA, September-November 1985 Memberships and editorial activities: Member of “Società Italiana per lo Studio dell’Aterosclerosi”, " Societa' Italiana di Ipertensione Arteriosa", "Council for High Blood Pressure Research", "Council on Epidemiology and Prevention", “International Atherosclerosis Society”, “American Society of Hypertension”. Occasional referee for major international journals. Meetings and publications: Active participant at various international meetings and author of more than 250 publications, including 67 full papers in peer-reviewed journals (7 national, 60 international journals), 9 book chapters and 187 abstracts.
	Qualifications and awards	Alunna del Collegio Ghislieri, Pavia Winner of various “Borsa di Studio” of Collegio Ghislieri, Pavia, Universita' degli Studi di Pavia and IRCCS-Pol S Matteo, Pavia Awarded European Specialist in Hypertension by the European Society of Hypertension
	Research interests	Pathophysiology and clinical aspects of Hypertension Pathophysiology of Atherosclerosis Pain perception
	Teaching experience and appointments	"Cultore della Materia" for Patologia Medica and Medicina Interna, 1994 “Ricercatore” in Internal Medicine, 1994 Associate Professor in Internal Medicine since 2002 Teaching Experience: Faculty of Medicine and Surgery: Nefrologia (Malattie del Rene e delle Vie Urinarie), 1998-1999, 1999-2000 and since 2002-2003 (corso Integrato di Patologia medica) Terapia Medica (Medicina Interna II), 1999-2000, 2000-2001; Terapia Medica e Medicina Termale (Medicina Interna), since 2001-2002 Pneumologia Sociale e Preventiva (corso integrato di Malattie dell’Apparato Respiratorio), 2000-2001, Malattie dell’Apparato Respiratorio (Patologia Medica), from 2001-2002 to 2004-2005 Gastroenterologia (Patologia Medica), 2000-2001 Teaching Experience: Others: Professor at the Faculty of Nursery Science Professor at various post doctoral Schools, University of Insubria Teaching Experience: At present: Professor of Nefrology (Patologia Medica) and Professor of Medical Therapy (Medicina Interna) at the School of Medicine at the University of Insubria Professor of Nefrology (Medicina Clinica e Specialistica) at the Faculty of Nursery Science, University of Insubria Professor at various post doctoral Schools, University of Insubria
	Representative publications	1. GAUDIO G, GUASTI L., SCHIZZAROTTO A, SIMONI C, CRESPI C, KLERSY C, CIMPANELLI MG, RIGANTI G, GRANDI AM, VENCO A. (2005). Changes in plasma lipids during renin - angiotensin - system blockade by combination therapy (enalapril plus valsartan ) in patients with diabetes and hypertension. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. vol. 45, pp. 362-366 2. GUASTI L., SIMONI C, MAINARDI LT, CIMPANELLI MG, CRESPI C, GAUDIO G, KLERSY C, GRANDI AM, CERUTTI S, VENCO A. (2005). Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node. ACTA CARDIOLOGICA. vol. 60, pp. 319-324 3. GUASTI L., SIMONI C, MAINARDI LT, CRESPI C, CIMPANELLI MG, KLERSY C, GAUDIO G, GRANDI AM, CERUTTI S, VENCO A. (2005). Global link between heart rate and blood pressure oscillations at rest and during mental arousal in normotensive and hypertensive subjects. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. vol. 120, pp. 80-87 4. GRANDI, R LAURITA E, SELVA E, PIANTANIDA E, IMPERIALE D, GIOVANELLA L, GUASTI L, VENCO A. (2004) Natriuretic peptides as markers of preclinical cardiac disease in obesity. EUR J CLIN INVEST. vol. 34, pp. 342-8. 5. GRANDI AM, IMPERIALE D, SANTILLO R, BARLOCCO E, BERTOLINI A, GUASTI L., VENCO A. (2002). Aldosterone antagonist improves diastolic function in essential hypertension. HYPERTENSION. vol. 40, pp. 647-652AM 6. GUASTI L., ZANOTTA D, DIOLISI A, GARGANICO D, SIMONI C, GAUDIO G, GRANDI AM, VENCO A. (2002). Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade. JOURNAL OF HYPERTENSION. vol. 20, pp. 485 – 491 7. GUASTI L., ZANOTTA D, MAINARDI LT, PETROZZINO MR, GRIMOLDI P, GARGANICO D, DIOLISI A, GAUDIO G, KLERSY C, GRANDI AM, SIMONI C, CERUTTI S. (2002). Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. vol. 99, pp. 127 – 133 8. AM GRANDI, P ZANZI, R BROGGI, A FACCHINETTI, GUASTI L., L CERIANI, A VENCO. (2001). Longitudinal changes of insulin sensitivity in essential hypertension: influence of blood pressure control and familial predisposition to hypertension. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. vol. 86, pp. 3027-3031 9. AM GRANDI, R BROGGI, S COLOMBO, R SANTILLO, D IMPERIALE, A BERTOLINI, GUASTI L., A VENCO. (2001). Left ventricular changes in isolated office hypertension: a blood pressure matched comparison with normotension and sustained hypertension. ARCHIVES OF INTERNAL MEDICINE. vol. 161, pp. 2677-2681 10. GUASTI L., PETROZZINO MR, MAINARDI LT, GRIMOLDI P, ZANOTTA D, GARGANICO D, DIOLISI A, SIMONI C, GRANDI AM, GAUDIO G, CERUTTI S, VENCO A. (2001). Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hypertension patients. ACTA CARDIOLOGICA. vol. 56, pp. 289 – 295 11. GUASTI L., PETROZZINO MR, MAINARDI LT, GRIMOLDI P, ZANOTTA D, GARGANICO D, DIOLISI A, SIMONI C, GRANDI AM, GAUDIO G, CERUTTI S, VENCO A. (2001). Autonomic function and baroreflex sensitivity during angiotensin-converting enzyme inhibition or angiotensin II AT-1 receptor blockade in essential hytpertensive patients. ACTA CARDIOLOGICA. vol. 56, pp. 289-295 12. GRANDI AM, ZANZI P, FACCHINETTI A, GAUDIO G, CERIANI L, BERTOLINI A, GUASTI L., VENCO A. (1999). Insulin and diastolic dysfunction in lean and obese hypertensives. Genetic influence. HYPERTENSION. vol. 34, pp. 1208-1214 13. GUASTI L., GAUDIO G, ZANOTTA D, GRIMOLDI P, PETROZZINO MR, TANZI F, BERTOLINI A, GRANDI AM, VENCO A. (1999). Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity. PAIN. vol. 82, pp. 311 – 317 14. GUASTI L., GRIMOLDI P, MAINARDI LT, PETROZZINO MR, PIANTANIDA E, GARGANICO D, DIOLISI A, ZANOTTA D, BERTOLINI A, AGENO W, GRANDI AM, CERUTTI S, VENCO A. (1999). Autonomic function and baroreflex sensitivity during a normal ovulatory cycle in humans. ACTA CARDIOLOGICA. vol. 54, pp. 209 – 213 15. GUASTI L., ZANOTTA D, PETROZZINO MR, GRIMOLDI P, DIOLISI A, GARGANICO D, GAUDIO G, GRANDI AM, BERTOLINI A, VENCO A. (1999). Relationship between dental pain perception and 24 hour ambulatory blood pressure: a study on 181 subjects. JOURNAL OF HYPERTENSION. vol. 17, pp. 1799 – 1804 16. GUASTI L., A DIOLISI, G GAUDIO, P GRIMOLDI, R PETROZZINO, S USLENGHI, A BERTOLINI, AM GRANDI, A VENCO. (1998). Reactivity of blood pressure to mental arthmetic stress test, stress test recovery time, and ambulatory blood pressure in hypertensive and normotensive subjects. BLOOD PRESSURE MONITORING. vol. 3, pp. 275-280 17. GUASTI L., P GRIMOLDI, A DIOLISI, MR PETROZZINO, G GAUDIO, AM GRANDI, MG ROSSI, A VENCO. (1998). Treatment with enalapril modifies the pain perception pattern in hypertensive patients. HYPERTENSION. vol. 31, pp. 1146-1150 18. GRANDI AM, PINOTTI G, MORANDI E, ZANZI P, BULGHERONI P, GUASTI L., BERTOLINI A, VENCO A. (1997). Noninvasive evaluation of cardiotoxicity of 5-fluorouracil and low doses of folinic acid: a one year follow-up study. ANNALS OF ONCOLOGY. vol. 8, pp. 705-708 19. GUASTI L., F MARINO, G GAUDIO, M COSENTINO, A DIOLISI, A BERTOLINI, AM GRANDI, S LECCHINI, GM FRIGO, A VENCO. (1997). Ambulatory blood pressure, nocturnal blood pressure reduction and plasma catecholamines. ACTA CARDIOLOGICA. vol. 6, pp. 485-494 20. GUASTI L., P GRIMOLDI, L CERIANI, G GAUDIO, A BERTOLINI, L GIOVANELLA, AM GRANDI, G RONCARI, A VENCO. (1997). Atrial natriuretic peptide and 24 h blood pressure. BLOOD PRESSURE MONITORING. vol. 2, pp. 89-92 21. GUASTI L., R CATTANEO, A DANERI, L BIANCHI, G GAUDIO, MB REGAZZI, AM GRANDI, A BERTOLINI, E RESTELLI, A VENCO. (1996). Endogenous beta-endorphins in hypertension: correlation with 24-hour ambulatory blood pressure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 28, pp. 1243-1248 22. GUASTI L., B MERLO, R VERGA, R CATTANEO, G GAUDIO, L BIANCHI, P ZANZI, AM GRANDI, PM BOSSI, A VENCO. (1995). Effects of arithmetic mental stress test on hypertension-related hypalgesia. JOURNAL OF HYPERTENSION. vol. 13, pp. 1631-1635 23. GUASTI L., R CATTANEO, O RINALDI, MG ROSSI, L BIANCHI, G GAUDIO, AM GRANDI, G GORINI. A VENCO. (1995). Twenty-four hour noninvasive blood pressure monitoring and pain perception. HYPERTENSION. vol. 25, pp. 1301-1305 24. C FALCONE, GUASTI L., M OCHAN, S CODEGA, M TORTORICI, L ANGOLI, R BERGAMASCHI, C MONTEMARTINI. (1993). Beta-endorphins during coronary angioplasty in patients with silent or symptomatic myocardial ischemia. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 22, pp. 1614-1620 25. G SPECCHIA, C FALCONE, E TRAVERSI, MT LA ROVERE, GUASTI L., G DEMICHELI, D ARDISSINO, S DE SERVI. (1991). Mental stress as a provocative test in patients with various clinical syndromes of coronary artery disease. CIRCULATION. vol. 83, pp. 108-114 26. C FALCONE, G SPECCHIA, R RONDANELLI, GUASTI L., G CORSICO, S CODEGA, C MONTEMARTINI. (1988). Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 11, pp. 719-723 27. C FALCONE, R SCONOCCHIA, GUASTI L., S CODEGA, C MONTEMARTINI, G SPECCHIA. (1988). Dental pain threshold and angina pectoris in patients with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. vol. 12, pp. 348-352 28. M CHIMIENTI, M MOIZI, C KLERSY, GUASTI L., J A SALERNO. (1987). A modified ajmaline test for prediction of the effective refractory period of the accessory pathway in the Wolff-Parkinson-White syndrome. AMERICAN JOURNAL OF CARDIOLOGY. vol. 59, pp. 164-165 29. M CHIMIENTI, M MOIZI, J A SALERNO, C KLERSY, GUASTI L., M PREVITALI, E MARANGONI, C MONTEMARTINI, P BOBBA. (1987). Electrophysiologic and clinical effects of intravenous and oral encainide in patients with Wolff-Parkinson-White syndrome and paroxysmal atrial fibrillation. EUROPEAN HEART JOURNAL. vol. 8, pp. 282-290 30. J A SALERNO, M PREVITALI, C PANCIROLI, C KLERSY, M CHIMIENTI, M REGAZZI BONORA, E MARANGONI, C FALCONE, GUASTI L., C CAMPANA, R RONDANELLI. (1986). Ventricular arrhythmias during acute myocardial ischemia in man. The role and significance of R-ST-T alternance and the prevention of ischemic sudden death by medical treatment. EUROPEAN HEART JOURNAL. vol. 7, pp. 63-75

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