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The University of Insubria
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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Luigi Bartalena
The University of Insubria CV
 

Contact data

Full Professor
Department of Clinical Medicine
c/o Ospedale di Circolo, Division of Endocrinology
Viale Borri, 57 - 21100 Varese - Italy
Tel: +39 (0)332 278561
Fax: +39 (0)332 278358;
E-mail: luigi.bartalena@uninsubria.it | l.bartalena@libero.it
 

Biography

 Place and date of birth
Pisa, November 21, 1950.

Present position
Full Professor of Endocrinology; Director, Postdoctoral School of Endocrinology, University of Insubria; Head, Division of Endocrinology, Ospedale di Circolo, Varese

Education
- Baccalaureate (“Maturità Classica”), Liceo Classico G. Galilei, Pisa, 1969;

- M.D. Degree (magna cum laude), University of Pisa, 1975;

- Specialty Degree (magna cum laude), University of Pisa Postdoctoral School of Endocrinology, 1978

Research Training
- Visiting Fellow, Clinical Endocrinology Branch, NIDDK, National Institutes of Health (NIH), Bethesda, USA, November 1981-April 1983;

- Visiting Associate, Clinical Endocrinology Branch, NIDDK, NIH, Bethesda, USA, April 1983-October 1983;

- Visiting Professor, Genetics and Biochemistry Branch, NIDDK, NIH, Bethesda, USA, September 1990-September 1991

Memberships
- Italian Society of Endocrinology (1977);
- European Thyroid Association (1981);
- American Thyroid Association (1983);
- American Endocrine Society (1984);
- British Society for Endocrinology (1999);
- European Group on Graves’ Orbitopathy (EUGOGO) (2005)

Editorial Activities
- Associate Editor, Journal of Endocrinological Investigation (JEI), 2002-2004;

- Editor for Clinical Endocrinology, JEI, 2004-;

- Referee for major endocrine and internal medicine journals

Grants
- Grants from CNR for international collaborations with NIH, 1984-1989;
- Grants from the University of Pisa, 1984-2000;
- Grants from the University of Insubria, 2001-;
- Grants from the Italian Ministry of Education, University and Research (MIUR), 1993-1998, 2002-2004, 2004-

Invited Talks
- 38 National Meetings;
- 39 International Meetings

Publications
615 publications, including 186 full papers on peer-reviewed international journals (cumulative impact factor: 712) and 138 book chapters or monographs
 

Qualifications and awards

 - Schering Prize of the Italian Society of Endocrinology, Verona 1988

- Harington-DeVisscher Prize of the European Thyroid Association, Dublin, 1992

- Italian Society of Endocrinology Foundation Award, Torino 1999
 

Research interests

 - Pathophysiology of the thyroid gland;
- Graves’ hyperthyroidism;
- Graves’ ophthalmopathy;
- Thyroid hormone binding proteins;
- Thyroid autoimmunity;
- Iodine- and amiodarone-induced thyroid dysfunction;
- Acromegaly
 

Teaching experience and appointments

 - Assistant Professor of Endocrinology, University of Pisa (1980-2000);

- Full Professor of Endocrinology (2000), University of Insubria at Varese

- Director, Postdoctoral School of Endocrinology (2003-), University of Insubria at Varese

- Deputy Rector for Research (2002-2005), University of Insubria at Varese
 

Representative  publications

(in international journals in English)

1. Bartalena L, Tata JR, Robbins J: Characterization of nascent and secreted thyroxine-binding globulin in cultured human hepatoma (Hep G2) cells. J Biol Chem 259: 13605, 1984.

2. Bartalena L, Robbins J: Effect of tunicamycin and monensin on secretion of thyroxine-binding globulin by cultured human hepatoma (Hep G2) cells. J Biol Chem 259: 13610, 1984.

3. Bartalena L, Grimaldi S, Fleischmann K, Robbins J: Biosynthesis of a novel thyroxine-binding protein (27 K protein) in human hepatoma (Hep G2) cells. Endocrinology 118: 2370, 1986.

4. Bartalena L, Martino E, Antonelli A, Pacchiarotti A, Robbins J, Pinchera A: Effect of the antileukemic agent L-asparaginase on thyroxine-binding globulin and albumin synthesis in cultured human hepatoma (Hep G2) cells. Endocrinology 119: 1185, 1986.

5. Bartalena L, Martino E, Pacchiarotti A, Grasso L, Aghini-Lombardi F, Buratti L, Bambini G, Breccia M, Pinchera A: Factors affecting suppression of endogenous thyrotropin secretion by thyroxine treatment: retrospective analysis in athyreotic and goitrous patients. J Clin Endocrinol Metab 64: 849, 1987.

6. Bartalena L, Robbins J, Pacchiarotti A, Martino E, Pinchera A: Further studies on the role of glycosylation in thyroxine-binding globulin (TBG) secretion by human hepatoma (Hep G2) cells. Endocrinology 121: 1497, 1987.

7. Bartalena L, Martino E, Falcone M, Buratti L, Grasso L, Mammoli C, Pacchiarotti A, Aghini-Lombardi F, Balzano S, Pinchera A: Evaluation of the nocturnal serum thyrotropin (TSH) surge, as assessed by TSH ultrasensitive assay, in patients receiving long term L-thyroxine suppression and in patients with various thyroid disorders. J Clin Endocrinol Metab 65: 1265, 1987.

8. Bartalena L, Marcocci C, Bogazzi F, Panicucci M, Lepri A, Pinchera A: Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism. N Engl J Med 321: 1349, 1989.

9. Bartalena L: Recent achievements in studies on thyroxine-binding proteins. Endocr Rev 11: 47, 1990.

10. Bartalena L, Martino E, Petrini L, Velluzzi F, Loviselli A, Grasso L, Mammoli C, Pinchera A: The nocturnal serum thyrotropin surge is abolished in patients with adrenocorticotropin (ACTH)-dependent or ACTH-independent Cushing's syndrome. J Clin Endocrinol Metab 72: 1195, 1991.

11. Bartalena L, Farsetti A, Flink IL, Robbins J: Effects of interleukin-6 on the expression of thyroid hormone-binding protein genes in cultured human hepatoblastoma-derived (Hep G2) cells. Mol Endocrinol 6: 935, 1992.

12. Bartalena L, Cossu E, Grasso L, Velluzzi F, Loviselli A, Cirillo R, Martino E: Relationship between nocturnal serum thyrotropin peak and metabolic control in diabetic patients. J. Clin. Endocrinol. Metab. 76: 983, 1993.

13. Bartalena L, Hammond GL, Farsetti A, Flink IL, Robbins J: Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells. Endocrinology 133: 291, 1993.

14. Bartalena L, Grasso L, Brogioni S, Aghini-Lombardi F, Braverman LE, Martino E: Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J. Clin. Endocrinol. Metab. 78: 423, 1994.

15. Bartalena L, Brogioni S, Grasso L, Rago T, Vitti P, Pinchera A, Martino E: Interleukin-6: a marker of thyroid-destructive processes?. J. Clin. Endocrinol. Metab. 79: 1414, 1994.

16. Bartalena L, Brogioni S, Grasso L, Bogazzi F, Burelli A, Martino E: Treatment of amiodarone-induced thyrotoxicosis: results of a prospective study. J. Clin. Endocrinol. Metab. 81: 2930, 1996.

17. Bartalena L, Marcocci C, Pinchera A: Treating severe Graves' ophthalmopathy. Bailliere's Clin Endocrinol Metab. 11: 521, 1997.

18. Bartalena L, Marcocci C, Bogazzi F, Manetti L, Tanda ML, Dell'Unto E, Bruno-Bossio G, Nardi M, Bartolomei MP, Lepri A, Rossi G, Martino E, Pinchera A: Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy.N. Engl. J. Med. 338: 73, 1998.

19. Bartalena L, Marcocci C, Tanda ML, Manetti L, Dell'Unto E, Bartolomei MP, Nardi M, Martino E, Pinchera A: Cigarette smoking and treatment outcomes in Graves' ophthalmopathy. Ann. Intern Med. 129: 632, 1998.

20. Bartalena L, Pinchera A, Marcocci C. Management of Graves' ophthalmopathy: reality and perspectives. Endocr Rev 21: 168, 2000.

21. Bartalena L, Marcocci C, Pinchera A. Graves’ ophthalmopathy: a preventable disease? Eur J Endocrinol 146: 457, 2002.

22. Bartalena L, Marcocci C, Gorman CA, Wiersinga WM, Pinchera A. Orbital radiotherapy for Graves’ ophthalmopathy: Useful or useless? Safe or dangerous? J Endocrinol Invest 26: 5, 2003.

23. Bartalena L, Tanda ML, Piantanida E, Lai A. Oxidative stress and Graves’ ophthalmopathy: in vitro studies and therapeutic implications. Biofactors 19: 155, 2003.

24. Bartalena L, Marcocci C, Pinchera A. Orbital radiotherapy for Graves’ ophthalmopathy. J Clin Endocrinol Metab 89: 13, 2004.

25. Bartalena L, Wiersinga WM, Tanda ML, Bogazzi F, Piantanida E, Lai A, Martino E: Diagnosis and management of amiodarone-induced thyrotoxicosis in Europe: results of an international survey among members of the European Thyroid Association. Clin Endocrinol 61: 494, 2004.

26. Bartalena L, Marcocci C, Pinchera A: Somatostatin analogs for Graves’ ophthalmopathy: do they bounce off like a rubber bullet? J Clin Endocrinol Metab 89: 5908, 2004.

27. Bartalena L, Bogazzi F, Pinchera A, Martino E: Treatment with thionamides before radioiodine therapy for hyperthyroidism: yes or no? J Clin Endocrinol Metab 90: 1256, 2005.

28. Bartalena L, Tanda ML, Bogazzi F, Piantanida E, Lai A, Martino E: An update on the pharmacological management of hyperthyroidism due to Graves’ disease. Exp Opin Pharmacother 6: 851, 2005.

29. Bartalena L, Tanda ML, Piantanida E, Lai A: Glucocorticoids and outcome of radioiodine therapy for Graves’ hyperthyroidism. Eur J Endocrinol 153: 13, 2005.

30. Bartalena L: Glucocorticoids for Graves’ ophthalmopathy: how and when. J Clin Endocrinol Metab 90: 5497, 2005.

 

Clinical interests

1. Physiology and pathophysiology of the thyroid gland, with particular reference to Graves’ hyperthyroidism and ophthalmopathy, iodine-induced thyroid disorders, hypothyroidism and thyroid autoimmunity, thyroid nodular disorders and neoplasms;

2. Diseases of the pituitary gland, with particular reference to pituitary adenomas, including prolactin-secreting, growth hormone-secreting, TSH-secreting, ACTH-secreting and nonfunctioning adenomas;

3. Polyglandular autoimmune disorders.

 
 
   
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