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The University of Insubria
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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Massimo Sisti
The University of Insubria CV
 

Contact data

Associate Professor
Department of Chemical and Environmental Sciences
Via Valleggio 11, I-22100 Como
Tel: +390312386440
Fax: +390312386449
E-mail: massimo.sisti@uninsubria.it
 

Biography

 Massimo Sisti was born in Milan (Italy) in 1949. He received his Laurea degree in Chemistry in 1973 (University of Milano). During the period 1974-1983 he carried out his research in the group of Professor Jommi at the same University and supported Organic Chemistry classes as a tutor. In 1983 he got a permanent position as a Researcher in Organic Chemistry at the Faculty of Sciences of University of Milan. He continued his research activity in collaboration with Professor Jommi. In 1998 he was appointed Associate Professor at the University of Insubria-Como, School of Sciences.
 

Qualifications and awards

 Member of the Italian Chemical Society

Member of the regional (Lombardia) committee of the Italian Chemical Society
 

Research interests

 Massimo Sisti’s research interests mainly deal with the following topics: a) structural, synthetic and spectroscopic investigations of natural organic compounds b) new synthetic methodologies in Organic Chemistry c) synthesis of new polidentate ligands and of the corresponding paramagnetic metal ion complexes as contrast agents in Magnetic Resonance Imaging. He is co-author of 81 papers on international journals, 4 patents and about 40 communications in National and International Meetings.

National collaborations:
Prof.G.Palmisano, Università dell’Insubria
Prof. S.Aime, Università di Torino
Prof. G.B.Giovenzana, Università del Piemonte Orientale
Prof.F.Orsini, Università di Milano
Dr.R.Pagliarin, Università di Milano
Bracco Imaging SpA
 

Teaching experience and appointments

Current academic courses:

Organic Chemistry

Basic Principles of Macromolecular Chemistry

Advanced Organic Chemistry
 

Representative  publications

S. Aime, M. Botta, L. Frullano, S. Geninatti Crich, G.B. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti  CONTRAST AGENTS FOR MRI: A NOVEL ROUTE TO ENHANCED RELAXIVITIES BASED ON THE INTERACTION OF A Gd-CHELATE WITH POLY-b-CYCLODEXTRINS, Chem.Eur.J., 1999, 5(4), 1253-1260.

S. Aime, M. Botta, L. Frullano, S. Geninatti Crich, G.B. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti  NOVEL PARAMAGNETIC MACROMOLECULAR Gd(III) COMPLEX TO POLYAMINO ACIDS THROUGH A SQUARIC ACID MOIETY  Bioconjug. Chem., 1999, 10, 192-199

S. Aime, M. Botta, S. Geninatti Crich, G.B. Giovenzana, G. Palmisano, M. Sisti A MACROMOLECULAR COMPLEX AS A pH-RESPONSIVE RELAXOMETRIC PROBE FOR MRI APPLICATIONS J. Chem. Soc., Chem. Commun. 1999, 16, 1577-1578.

G.B. Giovenzana, R. Pagliarin, G. Palmisano, T. Pilati, M. Sisti  CAMPHOR-BASED OXAZAPHOSPHOLANES AS CHIRAL TEMPLATES FOR THE ENANTIOSELECTIVE SYNTHESIS OF a-
CHLOROPHOSPHONIC ACIDS  Tetrahedron: Asymmetry 1999, 10, 4277-4280.

A.Chellini, G.B. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti  DIETHOXYPHOSPHORYL AS A PROTECTING-ACTIVATING GROUP IN THE SYNTHESIS OF POLYAZACYCLOPHANES  Helv. Chim. Acta  2000, 83, 793-800.

V. Boldrini, G.B. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti  EXPEDITIOUS N-MONOALKYLATION OF 1,4,7,10 TETRAAZACYCLODODECANE (CYCLEN) VIA FORMAMIDO PROTECTION  Tetrahedron Lett. 2000, 41, 6527-6530.

S. Aime, M. Botta, E. Garino, S. Geninatti-Crich, G. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti  NON-COVALENT CONJUGATES BETWEEN CATIONIC POLYAMINO ACIDS AND Gd(III) CHELATES: A ROUTE FOR SEEKING ACCUMULATION OF MRI-CONTRAST AGENTS AT TUMOUR TARGETING SITES  Chem. Eur. J. 2000, 6, 2609-2617.

S. Aime, E. Gianolio, E: Terreno, G.B. Giovenzana, R. Pagliarin, M. Sisti, G. Palmisano, M. Botta, M.P. Lowe, D. Parker  TERNARY Gd(III)-HSA ADDUCTS: EVIDENCE FOR THE REPLACEMENT OF INNER-SPHERE WATER MOLECULES BY COORDINATING GROUPS OF THE PROTEIN. IMPLICATIONS FOR THE DESIGN OF CONTRAST AGENTS FOR MRI  J. Biol. Inorg. Chem. 2000, 5, 488-497.

S.Aime, M.Botta, L.Frullano, S.Geninatti Crich, G.B.Giovenzana, R.Pagliarin, G.Palmisano, F.R.Sirtori, M.Sisti [GdPCP(H2O)]- A PARAMAGNETIC CONTRAST AGENT DESIGNED FOR IMPROVED APPLICATIONS IN MAGNETIC RESONANCE IMAGING J.Med.Chem. 2000, 43, 4017-4024.

G. Cravotto, G.B. Giovenzana, R. Pagliarin, G. Palmisano, M. Sisti CAMPHOR-BASED CHIRAL AUXILIARY. FORMAL SYNTHESIS OF ENANTIOMERICALLY ENRICHED b-AMINOPHOSPHONIC ACIDS VIA PTC ALKYLATION  Synth.Commun. 2001, 31, 1013-1020

G.Cravotto, G.B.Giovenzana, T.Pilati, M..Sisti, G.Palmisano AZOMETHINE YLIDE CYCLOADDITION/REDUCTIVE HETEROCYCLIZATION APPROACH TO OXINDOLE ALKALOIDS: ASYMMETRIC SYNTHESIS OF (-)-HORSFILINE J.Org.Chem.2001, 66, 8447-8453

S.Aime, G.Cravotto, S.Geninatti Crich, G.B.Giovenzana, M.Ferrari, G.Palmisano, M.Sisti SYNTHESIS OF THE Gd(III) COMPLEX WITH A TETRAZOLE-ARMED MACROCYCLIC LIGAND AS A POTENTIAL MRI CONTRAST AGENT Tetrahedron Lett. 2002, 43, 783-786

S.Aime, C.Cavallotti, E.Gianolio, G.B.Giovenzana, G.Palmisano, M.Sisti  ONE-STEP SYNTHESIS OF A NEW EIGHT-MEMBERED CYCLIC LIGAND FROM GLYCINE , FORMALDEHYDE AND HYPOPHOSPHOROUS ACID  Tetrahedron Lett. 2002, 43, 8387-8389

A.Caselli, G.B.Giovenzana, G.Palmisano, M.Sisti , T.Pilati  SYNTHESIS OF C2- SYMMETRICAL DIAMINE BASED ON (1R)-(+)-CAMPHOR AND APPLICATION TO OXIDATIVE ARYL COUPLING OF NAPHTHOLS. Tetrahedron:Asymmetry 2003, 1451-1454

S.Aime, E.Gianolio, D.Corpillo, C.Cavallotti, G.Palmisano, M.Sisti, G.B.Giovenzana, R.Pagliarin. DESIGNING NOVEL CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING. SYNTHESIS AND RELAXOMETRIC CHARACTERIZATION OF THREE GADOLINIUM (III) COMPLEXES BASED ON FUNCTIONALIZED PYRIDINE-CONTAINING MACROCYCLIC LIGANDS. Helv.Chim.Acta  2003, 86, 615-632.

S.Aime, C.Cavallotti, E.Gianolio, G.B.Giovenzana, G.Palmisano, M.Sisti,   MANNICH REACTION AS A NEW ROUTE TO PYRIDINE-BASED POLYAMINOCARBOXYLIC LIGANDS. Org.Lett. 2004, 6, 1201-1204.

S.Aime, L.Calabi, C.Cavallotti, E.Gianolio, G.B.Giovenzana, P.Losi, A.Maiocchi, G.Palmisano, M.Sisti,  [Gd-AAZTA]- : A NEW STRUCTURAL ENTRY FOR AN IMPROVED GENERATION OF MRI CONTRAST AGENTS. Inorg.Chem. 2004, 43, 7588-7590.

S.Aime, E.Gianolio, D.Longo, R.Pagliarin, C.Lovazzano, M.Sisti,  NEW INSIGHTS FOR PURSUING HIGH RELAXIVITY MRI AGENTS FROM MODELING THE BINDING INTERACTION OF GdIII CHELATES TO HSA. ChemBioChem 2005, 6, 818-820.

S.Aime, M.Botta, G.Cravotto, L.Frullano, G.B.Giovenzana, S.Geninatti Crich, G.Palmisano, M.Sisti,   GADOLINIUM (III) COMPLEXES OF DOTA-DERIVED N-SULFONYLACETAMIDES (H4(dota-NHSO2R)=10-{2-[(R)sulfonylamino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid):  A NEW CLASS OF RELAXATION AGENTS FOR MAGNETIC RESONANCE IMAGING APPLICATIONS.  Helv.Chim.Acta 2005, 88, 588-603.
 
   
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