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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Umberto Piarulli
The University of Insubria CV
 

Contact data

Associate Professor
Department of Chemical and Environmental Sciences
Via Valleggio, 11 22100 Como
Tel: 031-238 6444
Fax: 031-238 6449
E-mail: Umberto.Piarulli@uninsubria.it
 

Biography

Umberto Piarulli was born in Varese (Italy) in 1965. After his primary and secondary school in Varese, in 1990 he obtained his “Laurea in Chimica” (MSC in Chemistry) at the University of Milano. From 1991 to 1996 he was a doctoral student in the group of Prof. C. Floriani (University of Lausanne, Switzerland) and he received his Ph.D. in 1996. His PhD thesis dealt with the synthesis of transition metal complexes of carbohydrate derivatives as oxygen rich ligands and promoters of novel architectures in coordination chemistry.

In 1996 he became researcher of organic chemistry at Milan University in the group of professor C. Gennari. In 1996 (summer) he was visiting scientist at the Cold Spring Harbor Laboratory (Cold Spring Harbor, NY 11724, USA). From 1998 to 2004 he was researcher of organic chemistry at the University of Insubria at Como. In 2002 he got his habilitation as Associate Professor of organic chemistry and in 2004 he was appointed Associate Professor of organic chemistry at the University of Insubria - Como. He is co-author of 46 research papers in refereed journals and 2 chapters in books.
 

Qualifications and awards

 His awards include: “Young Talented Organic Chemist Lecture” at the 12th European Symposium on Organic Chemistry (ESOC 12) (Groningen – NL, 2001); INNOVATEC Guest Chair on Combinatorial Chemistry and Solid Phase Synthesis (Insitut für Organische Chemie, Universität Regensburg, 2003); member of the managing council of the interuniversity consortium “Reattività Chimica e Catalisi” (Chemical Reactivity and Catalysis).
 

Research interests

His research interests include: (i) the design and development of new enantioselective methods, and their application to the synthesis of natural and unnatural targets; (ii) the solid phase synthesis of combinatorial libraries of organic compounds with interesting biological and chemical properties; (iii) the synthesis of combinatorial libraries of chiral ligands for enantioselective catalysis.

More recently his research interests include also the synthesis of unnatural amino acids with defined conformational properties in the frame of an EC funded project in collaboration with the University of Paris-Sud 11 and Regensburg (coordinator of the “Marie Curie Host Fellowships for Early Stage Researchers Training” project “Foldamers” contract MEST-CT-2004-515068).

Professor Piarulli has ongoing scientific collaborations with:

  • Prof. C. Gennari, University of Milano
  • Prof. J. G. de Vries, DSM-Research – Geleen (NL)
  • Prof. B. L. Feringa, University of Groningen (NL)
  • Prof. R. F. W. Jackson, University of Sheffield (UK)
  • Prof. O. Reiser University of Regensburg (DE)
  • Prof. S. Sicsic, University of Paris-Sud 11 (F)
 

Teaching experience and appointments

 Current academic courses:

1) “Metodi Fisici in Chimica Organica” (Advanced NMR and MS) - 2nd Semester, 3rd Year Laurea in Scienze Chimiche (First level degree in Chemical Sciences).

2) “Sintesi e Tecniche Speciali Organiche” (Advanced Synthetic Organic Chemistry) 1st Semester, 2nd year “Laurea Specialistica in Scienze Chimiche” (Second level degree in Chemical Sciences).

Invited Lectures:
”XXIV Scuola Nazionale di sintesi Organica” (Gargnano, ITALY, 1999).
“GraduiertenKolleg” (RWTH Aachen Germany, 2001).
“Secondo Laboratorio di Metodologie Sintetiche in Chimica Farmaceutica” (Università degli Studi di Siena, 2003)

Invited Seminars
1998 - University of Newcastle, Newcastle upon Tyne (UK).
1999 - Academy of Sciences, Prague (CZ).
2000 - Alfatech spa, Milan (IT).
2001- Expert Group Meeting on Trends and Applications of CC/CT/MD (Combinatorial Chemistry, Combinatorial Technologies, Molecular Dynamics) Trieste, (IT).
2003 - Institut für Organische Chemie, Universität Regensburg (DE).
 

Representative  publications

1) ”Diacetoneglucose Complexes of Manganese(II) and Iron(II) and Their Organometallic Derivatization.” Piarulli U.; Floriani C.; Re N.; Gervasio G.; Viterbo D. Inorg. Chem. 1998, 37, 5142.

2) ”Hydrogen-Bonding Donor/Acceptor Scales in b
-Sulfonamidopeptides.” Gennari C.; Gude M.; Potenza D.; Piarulli U. Chem. Eur. J. 1998, 4, 1924.

3) “Computer-Assisted Design and Synthetic Applications of Chiral Enol Borinates - Novel, Highly Enantioselective Aldol Reagents.” Gennari C.; Ceccarelli S.; Piarulli U.; Aboutayab K. J. Braz. Chem. Soc. 1998, 9, 319.

4) “Investigation of a New Family of Chiral Ligands for Enantioselective Catalysis via Parallel Synthesis and High-Throughput Screening.” Gennari C.; Ceccarelli S.; Piarulli U.; Montalbetti CAGN.; Jackson RFW. J. Org. Chem. 1998, 63, 5312.

5) ”Synthetic Studies on Sarcodictyins and Eleutherobin: Synthesis of Fully Functionalized Cyclization Precursors.” Ceccarelli S.; Piarulli U.; Gennari C. Tetrahedron Lett. 1999, 40, 153.

6) “Solid Phase Synthesis of Peptides Containing Reverse Turn Mimetic Bicyclic Lactams.” Gennari, C.; Mielgo, A.; Potenza, D.; Scolastico, C.; Piarulli, U.; Manzoni, L. Eur. J. Org. Chem. 1999, 379.

7) “Ureas: New Efficient Lewis Base Catalysts for the Allylation of Aldehydes.” Chataigner, I.; Piarulli, U.; Gennari, C. Tetrahedron Lett. 1999, 40, 3633.

8) “A Trifunctional Steroid-Based Scaffold for Combinatorial Chemistry” Barry, J.F.; Davis, A.P.; Perez-Payan, M.N.; Elsegood, M.R.J.; Jackson, R.F.W.; Gude, M.; Piarulli, U.; Gennari, C. Tetrahedron Lett. 1999, 40, 2849.

9) “Organometallic Compounds in Organic Synthesis.” Piarulli, U. In Seminars in Organic Synthesis XXIV Summer School “A Corbella” R. Riccio Ed., Società Chimica Italiana, 1999.

10) “Discovery of a New Efficient Chiral Ligand for Copper Catalyzed Enantioselective Michael Additions by High-Throughput Screening of a Parallel Library.” Chataigner, I.; Gennari, C.; Piarulli, U.; Ceccarelli S. Angew. Chem. Int. Ed. 2000, 39, 916.

11) “ The Effect of Ligands and Additives on the Palladium Promoted Carbonylative Coupling of Vinyl Stannanes and Electron-Poor Enol Triflates.” Ceccarelli, S.; Piarulli, U.; Gennari, C. J.Org.Chem. 2000, 65, 6254.

12) “Optimization of New Chiral Ligands for the Copper‑Catatlysed Enantioselective Conjugate Addition of Et2Zn to Nitroolefins by High‑Throughpur Screening of a Parallel Library.” Ongeri, S.; Piarulli, U.; Jackson, R.F.W.; Gennari, C. Eur. J. Org. Chem. 2001, 803.

13) “Discovery of a New Efficient Chiral Ligand for Copper Catalyzed Enantioselective Michael Additions by High-Throughput Screening of a Parallel Library.” Chataigner, I.; Gennari, C.; Ongeri, S.; Piarulli, U.; Ceccarelli S. Chem. Eur. J. 2001, 7, 2628.

14) “Enantioselective Binding of Dipeptides using Acyclic Receptors” Botana, E.; Ongeri, S.; Arienzo, R.; Demarcus, M.; Frey, J.G.; Piarulli, U.; Potenza, D.; Gennari, C.; Kilburn, J.D. Chem. Commun. 2001, 1358.

15) ”Synthetic Studies on the Sarcodictyins: Synthesis of Fully Functionalized Cyclization Precursors.” Ceccarelli S.; Piarulli U.; Gennari C. Tetrahedron 2001, 57, 8531.

16) “A Carbonylative Cross-Coupling Strategy to the Total Synthesis of the Sarcodictyins: Preliminary Studies and Synthesis of a Cyclization Precursor” Ceccarelli S.; Piarulli U.; Telser, J.; Gennari C. Tetrahedron Lett. 2001, 42, 7421.

17) “Synthesis, Conformational Studies and Binding Properties of Acyclic Receptors for N-Protected Aminoacids and Dipeptides” Botana, E.; Ongeri, S.; Arienzo, R.; Demarcus, M.; Frey, J.G.; Piarulli, U.; Potenza, D.; Kilburn, J.D.; Gennari, C. Eur. J. Org. Chem. 2001, 4, 4625.

18) “Cyclative Cleavage via Solid-Phase Supported Stabilized Sulfur Ylides: Synthesis of Macrocyclic Lactones” La Porta, E.; Piarulli, U.; Cardullo, F.; Paio, A.; Provera, S.; Seneci,  P.; Gennari  C. Tetrahedron Lett. . 2002, 43, 761

19) “Synthesis and Screening of New Chiral Ligands for the Copper Catalysed Enantioselective Allylic Substitution” Ongeri, S.; Piarulli, U.; Roux, M.; Monti, C.; Gennari, C. Helv. Chim. Acta, 2002, 85, 3388.

20) “A New Catalytic and Enantioselective Desymmetrization of Meso Cyclic Allylic Bisdiethylphosphates with Organozinc Reagents.” Piarulli, U.; Daubos, P.; Claverie, C.; Roux, M.; Gennari, C. Angew. Chem. Int. Ed. 2003, 42, 234.

21) “Combinatorial Libraries of Chiral Ligands for Enantioselective Catalysis” Gennari, C.; Piarulli, U. Chem. Rev. 2003, 103, 3071.

22) “Copper Phosphoramidite-Catalyzed Enantioselective Desymmetrization of meso-Cyclic Allylic Bisdiethyl Phosphates” Piarulli, U.; Daubos, P.; Claverie, C.; Gennari, C.; Minnaard, A. J.; Feringa, B. L. Org. Lett. 2003, 5, 4493.

23) “Copper Catalysed 1,4 Addition of Organozinc Reagents to a,b-Unsaturated Carbonyl Compounds: A Mechanistic Investigation” Gallo, E.; Ragaini, F.; Bilello, L.; Cenini, S.; Gennari, C.; Piarulli U. J. Organomet. Chem. 2004, 689, 2169.

24) “A Modular Approach to a New Class of Monodentate Chiral Phosphorus Ligands, and their Application in Enantioselective Copper-Catalysed Conjugate Additions of Diethylzinc to Cyclohexenone.” Monti, C.; Gennari, C.; Steele, R. M.; Piarulli, U. Eur. J. Org. Chem. 2004, 3557.

25) “Microwave-Assisted Solvent-free Synthesis of a Quinoline-3,4-Dicarboximide Library on Inorganic Solid Supports.” Mortoni, A.; Martinelli, M.; Piarulli, U.; Regalia, N.; Gagliardi S. Tetrahedron Lett. 2004, 45, 6623

26) “Rh-Catalysed Asymmetric Hydrogenations with a Dynamic Library of Chiral Tropos Phosphorus-Ligands.” Monti, C.; Gennari, C.; Piarulli, U. Tetrahedron Lett. 2004, 45, 6859.

27) “6.1.10 Product Subclass 10: Vinyloxyboranes” Gennari, C.; Ceccarelli, S.; Piarulli, U. In “Science of Synthesis, Houben‑Weyl Methods of Molecular Transformations” Vol. 6 Boron Compounds, Kaufmann and D. S. Matteson Eds., Georg Thieme Verlag, Stuttgart DE, 2005, pp. 337.

28) “Copper-catalysed Enantioselective Desymmetrisation of meso Cyclic Allylic Bis(diethyl phosphates) with Organozinc Reagents” Piarulli, U.; Daubos, P.; Claverie, C.; Monti, C; Gennari, C.; Eur. J. Org. Chem. 2005, 895.

29) “Rh-catalysed asymmetric hydrogenation of prochiral olefins with a dynamic library of chiral tropos phosphorus ligands” Gennari, C.; Monti, C.; Piarulli, U.; de Vries, J. G.; de Vries, A. H. M.; Lefort L. Chem. Eur. J. 2005, 11, 6698.

30) Enantioselective Conjugate Addition of Phenylboronic Acid to Enones Catalyzed by a Chiral Tropos/Atropos Rhodium Complex at the Coalescence Temperature Monti, C.; Gennari, C.; Piarulli, U. Chem. Commun. 2005, 5281.

 

 
 
   
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