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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Giovanni Bernardini
The University of Insubria CV
 

Contact data

Full Professor
Department of Biotechnology and Molecular Sciences
Via Dunant 3 – I-21100 Varese
Tel: ++39 0332 421316
Fax: ++39 0332 421500
E-mail: giovanni.bernardini@uninsubria.it

 

Biography

Giovanni Bernardini, born in Milano on August 28, 1955, is a professor of the Department of Biotechnology and Molecular Sciences in the University of Insubria. After obtaining his Doctorate degree in Biology in 1979 at the University of Milan, he was a Postdoctoral Research Associate in the Department of Physiology of the University of Rochester, N.Y. until 1983 where he studied intercellular junctions.

In the Department of Biology in the University of Milan he worked on gamete biology using as a model the anuran Xenopus laevis. He studied sperm motility, sperm ultrastructure and biochemistry as well as the last phases of the spermiogenesis. He approached fertilization by means of electrophysiological and morphological techniques. For this research, presented at different Gordon Conferences, he collaborated with Marie Paule Cosson of the CNRS di Villefranche sM and with Jerry Hedrick of the University of California at Davis where he has been an Associate in the Experimental Station in 1987.

 

Research interests

Lately, Xenous embryos have been used for the development of a bioassay for evaluating the teratogenic risk. In 2000, he was invited by the Department of Health and Human Services to serve as a member of an Expert Panel “to assess the current validation status of FETAX”. He is also collaborating with ECVAM of the Joint Research Centre (Ispra) to study gene expression modifications induced by metals.

Recently, molecular biology techniques were used to follow a gene during vertebrate evolution and to search for genes whose expression is modified by metals. Stress-related genes in fishes are also studied.
 

Teaching experience and appointments

He teaches Cell Biology, Histology, and Developmental Biology in different courses. He has been Director of the Department of Structural and Functional Biology and he is Coordinator of the Ph.D. in Cell and Molecular Biology.
 

Representative  publications

BERNARDINI G., PRATI M., GORNATI R. (2005). FETAX, a versatile tool in toxicology, can be conveniently integrated with molecular biology techniques. APPLIED HERPETOLOGY. vol. 2, pp. 287-295 ISSN: 1570-7539.

GORNATI R., GUALDONI S., CAVALIERE R., TEROVA G., SAROGLIA M., BERNARDINI G. (2005). Molecular biology and fish welfare: a winning combination. AQUACULTURE INTERNATIONAL. vol. 13, pp. 51-55 ISSN: 0967-6120.

GORNATI R, PAPIS E, RIMOLDI S, CHINI V, TEROVA G, PRATI M, SAROGLIA M, BERNARDINI G. (2005). Molecular markers for animal biotechnology: sea bass (Dicentrarchus labrax, L.) HMG-CoA reductase mRNA. GENE. vol. 344, pp. 299-305 ISSN: 0378-1119.

TEROVA G, GORNATI R, RIMOLDI S, BERNARDINI G., SAROGLIA M. (2005). Quantification of a glucocorticoid receptor in sea bass (Dicentrarchus labrax, L.) reared at high stocking density. GENE. vol. 357, pp. 144-151 ISSN: 0378-1119.

TEROVA, G., BERNARDINI G., GORNATI, R., SAROGLIA, M. (2005). cDNA encoding sequences for myostatin and FGF6 in sea bass (Dicentrarchus labrax, L) and the effect of fasting and refeeding on their expression levels. DOMESTIC ANIMAL ENDOCRINOLOGY. ISSN: 0739-7240.

GORNATI R., PAPIS E., RIMOLDI S., TEROVA G., SAROGLIA M., BERNARDINI G. (2004). Rearing density influences the expression of stress-related genes in sea bass (Dicentrarchus labrax, L.). GENE. vol. 341, pp. 111-118 ISSN: 0378-1119.

GORNATI R., TEROVA G., VIGETTI D., PRATI M., SAROGLIA M., BERNARDINI G. (2004). Effects of population density on sea bass (Dicentrarchus labrax) gene expression. AQUACULTURE. vol. 230, pp. 229-239 ISSN: 0044-8486.

RIBAS, L., PLANAS, J.V., BARTON, B., MONETTI, C., BERNARDINI G., SAROGLIA, M., TORT, L., MACKENZIE, S. (2004). A differentially expressed enolase gene isolated from the gilthead sea bream (Sparus aurata) under high-density conditions is up-regulated in brain after in vivo lipopolysaccharide challenge. AQUACULTURE. vol. 241, pp. 195-206 ISSN: 0044-8486.

CINQUETTI R., MAZZOTTI F., AQUATI F., GORNATI R., SABBIONI E., TARAMELLI R., BERNARDINI G. (2003). Influence of metal ions on gene expression of BALB 3T3 fibroblasts. GENE. vol. 318, pp. 83-89 ISSN: 0378-1119.

MONETTI C., VIGETTI D., PRATI M., GORNATI R., FORTANER S., SABBIONI E., BERNARDINI G. (2003). Platinum toxicity and gene expression in Xenopus embryos: analysis by FETAX and differential display. ATLA. ALTERNATIVES TO LABORATORY ANIMALS. vol. 31, pp. 401-408 ISSN: 0261-1929.

VIGETTI C., BINELLI G., MONETTI C., PRATI M., BERNARDINI G., GORNATI R. (2003). Selective pressure on the allantoicase gene during vertebrate evolution. JOURNAL OF MOLECULAR EVOLUTION. vol. 57, pp. 650-658 ISSN: 0022-2844.

VIGETTI D., VIOLA M., GORNATI R., ORI M., NARDI I., PASSI A., DE LUCA G., BERNARDINI G. (2003). Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3. MATRIX BIOLOGY. vol. 22, pp. 511-517 ISSN: 0945-053X.

GORNATI R., MONETTI C., VIGETTI D., BOSISIO S., FORTANER S., SABBIONI E., BERNARDINI G., PRATI M. (2002). Arsenic toxicity and HSP70 expression in Xenopus laevis embryos. ATLA. ALTERNATIVES TO LABORATORY ANIMALS. vol. 30, pp. 597-603. ISSN: 0261-1929.

MONETTI C., VIGETTI D., PRATI M., GORNATI R., BERNARDINI G. (2002). Identification and molecular cloning of Xenopus laevis SP22, a protein associated with fertilization in mammals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY. vol. 132, pp. 761-767 ISSN: 1096-4959.

MONETTI C., VIGETTI D., PRATI M., SABBIONI E., BERNARDINI G., GORNATI R. (2002). Gene expression in Xenopus embryos after methylmercury exposure: a search for molecular biomarkers. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. vol. 21, pp. 2731-2736 ISSN: 0730-7268.

PRATI M., GORNATI R., BORACCHI P., BIGANZOLI E., FORTANER S., PIETRA R., SABBIONI E., BERNARDINI G. (2002). A comparative study of the toxicity of mercury dichloride and methylmercury, assayed by the frog embryo teratogenesis assay-Xenopus (FETAX). ATLA. ALTERNATIVES TO LABORATORY ANIMALS. vol. 30, pp. 23-32 ISSN: 0261-1929.

PRATI M., MOLTENI M., POMATI F., ROSSETTI C., BERNARDINI G. (2002). Biological effect of the Planktothrix sp. FP1 cyanobacterial extract. TOXICON. vol. 40, pp. 267-272 ISSN: 0041-0101.

RIZZO A.M., BERRA B., ROSSI F., GUERRA A., GORNATI R., BERNARDINI G., TAKI T., KASAMA T., MAURI L., SONNINO S. (2002). Structure of the main ganglioside from the brain of Xenopus laevis. GLYCOCONJUGATE JOURNAL. vol. 19, pp. 53-57. ISSN: 0282-0080.

VIGETTI D., MONETTI C., PRATI M., GORNATI R., BERNARDINI G. (2002). Genomic organization and chromosome localization of the murine and human allantoicase gene. GENE. vol. 289, pp. 13-17 ISSN: 0378-1119.

VIGETTI D., POLLEGIONI L., MONETTI C., PRATI M., BERNARDINI G., GORNATI R. (2002). Property comparison of recombinant amphibian and mammalian allantoicases. FEBS LETTERS. vol. 512, pp. 323-328 ISSN: 0014-5793.

RIZZO A.M., ROSSI F., GUERRA A., BERRA B., GORNATI R., BERNARDINI G., SONNINO S. (2001). Exogenous sphingosine is taken up and metabolised by Xenopus laevis embryos grown in Petri dishes. BIOSCIENCE REPORTS. vol. 21, pp. 719-731 ISSN: 0144-8463.

VIGETTI D., MONETTI C., BERNARDINI G. (2001). Molecular cloning of mouse allantoicase cDNA. BIOCHIMICA ET BIOPHYSICA ACTA. vol. 1519, pp. 117-121 ISSN: 0006-3002.

PRATI M., BIGANZOLI E., BORACCHI P., TESAURO M., MONETTI C., BERNARDINI G. (2000). Ecotoxicological soil evaluation by FETAX. CHEMOSPHERE. vol. 41, pp. 1621-1628 ISSN: 0045-6535.

VIGETTI D., MONETTI C., ACQUATI F., TARAMELLI R., BERNARDINI G. (2000). Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. GENE. vol. 256, pp. 253-260 ISSN: 0378-1119.

VIGETTI D., MONETTI C., POLLEGIONI L., TARAMELLI R., BERNARDINI G. (2000). Xenopus allantoicase: molecular cloning, enzimatic activity and developmental expression. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. vol. 379, pp. 90-96 ISSN: 0003-9861.

 

 
   
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