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The University of Insubria CV
The University of Insubria CV
The University of Insubria CV The University of Insubria CV Rosalba Gornati
The University of Insubria CV
 

Contact data

Assistant Professor
Department of Biotechnology and Molecular Science
Via J.H. Dunant, 3 21100 Varese I
Tel: +390332421444
Fax: +390332421500
E-mail: rosalba.gornati@uninsubria.it
 

Biography

July 1984: Bachelor Degree in Biological-medical Laboratory at the University of Milan. Title of the thesis: "New method to diagnosis sialoglycoconjugate diseases”.

September 1984 – September 1986: scholarship at the General Physiology and Biochemistry Institute, University of Milan..

October 1986 – March 1989: Junior laboratory technician at the General Physiology and Biochemistry Institute, University of Milan.

March 1990: Degree in Pharmacy at the University of Milan. Title of the thesis: "New method for serum gangliosidic sialic acid determination”.

1991: Teaching diploma for Nutrition Science.

March 1993 – September 1993 than October 1995 –November 1995 Visiting Researcher at the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame (Indiana, USA).

January 1996–December 1998 Senior laboratory technician at the General Physiology and Biochemistry Institute, University of Milan.

January 1999 – February 2002: Senior laboratory technician at the Department of Structural and Functional Biology, University of Insubria (VA, Italy).

March 2002 to Present: Research Associate at the Department of Biotechnology and Molecular Science, University of Insubria (VA, Italy).
 

Research interests

 STUDY ON MEMBRANE LIPID EXPRESSION as diagnostic method in sphingolipidosis and neoplasias, in this case by the search of “potential” biomarkers.

EVALUATION OF LIPID PATTERN IN XENOPUS LAEVIS EMBRYOS DURING DEVELOPMENT FETAX (Frog Embryo Teratogenesis Assay in Xenopus) has been widely used to assay toxic and teratogenic effects of various compounds; using Xenopus as a biological model it is possible to analyse a wide number of embryo pools and this makes the test statistically powerful. Morphological analysis alone is inadequate to understand the molecular mechanisms of embryo toxicity and teratogenesis, but it is the base to apply molecular techniques. Furthermore biochemical studies concerning glycolipid composition as also been performed.

GENETICAL AND EVOLUTIONARY STUDIES ON ALLANTOICASE an enzyme involved in purine catabolism that has been lost during vertebrate evolution.

SEARCH OF MOLECULAR BIOMARKERS in Dicentrarchus labrax by differential display to find mRNA differentially expressed in two population or before and after a treatment. With the aim to reduce the gap of genomic resources of commercial species classical, normalized and subtraction libraries have been made, screened and the sequences deposited in GenBank.

EXPRESSION IALURONIC ACID SYNTHASE 3 DURING Xenopus laevis DEVELOPMENT and its genomic organization.
 

Teaching experience and appointments

 2001/2002 CELLULAR BIOTECHNOLOGY University of Insubria, School of Sciences in Varese

2001/2002 2002/2003, 2003/2004, 2004/2005, 2005/2006 CITOLOGY and HISTOLOGY University of Insubria, School of Sciences in Varese

2002/2003, 2003/2004, 2004/2005, 2005/2006 LIFE SCIENCE University of Insubria, Faculty of Science.
 

Representative  publications

1. B. Berra, S. Rapelli, M. Brivio, R. Gornati, M.F. Omodeo Sale`. Modification of glycoconjugate content and distribution in human meningiomas. In: Clin Chem Enzymol Commun. (Melino G., Kemshead J.T., Knight R.A., Federici G., Guerrieri P., Schwab M. eds) Harwood Academic Publisher 2, 383-390 (1990).

2. R. Gornati, S. Rapelli, G. Montorfano, C. Cattaneo, B. Berra. A new procedure for gangliosidic N-acetylneuraminic acid analysis in serum. The International Journal of Biological Marker 6, 91-98 (1991).

3. G. Bernardini, R. Gornati, S. Rapelli, F. Rossi and B. Berra. Lipids Xenopus laevis spermatozoa. Development Growth & Differentiation 34(3), 329-335 (1992).

4. B. Bembi, M. Comelli, B. Scaggiante, A. Pineschi, S. Rapelli, R. Gornati, G. Montorfano, B. Berra, E. Agosti and D. Romeo. Treatment of sphingomyelinase deficiency by repeated implantation of amniotic ephitelial cells. American Journal of Medical Genetics 44, 527-533 (1992).

5. A.M. Rizzo, R. Gornati, C. Galli, G. Bernardini and B. Berra. Cholesterol, Triacylglicerol and Phospholipids Durind Xenopus Embryo Development. Cell Biology International, 18/11, 1085-1090 (1994).

6. B. Bembi, M. Zanatta, M. Carrozzi, F. Baralle, R. Gornati, B. Berra and E. Agosti. Enzyme replacement treatment in type 1 and 3 Gaucher's disease. Lancet, 344, 1679-1682 (1994).

7. R. Gornati, A.M. Rizzo, X.W. Tong, B. Berra and G. Bernardini. Glycolipid patterns during Xenopus embryo development. Cell Biology International 19/3, 183-189 (1995).

8. B. Berra, R. Gornati, S. Rapelli, R. Gatti, G.M.S. Mancini and B. Bembi. Infantile sialic acid storage disease: biochemical studies. American J. of Medical Genetics 58, 24-31 (1995).

9. A.M. Rizzo, R. Gornati, F. Rossi, G. Bernardini and B. Berra. Retinoic acid induces changes in Xenopus embryo glycolipid pattern. Cell Biology International 19/11, 895-901 (1995).

10. M.F. Omodeo-Sale', R. Gornati and P. Palestini. Ganglioside Long-Chain Base Composition of Rat Brain Subcellular Fractions after Chronic Ethanol Administration. Alcohol 13/3, 291-295 (1996).

11. G. Bernardini, A. M. Rizzo, R. Gornati, F. Rossi and B. Berra. Tissue and developmental specificity of a polysialo-ganglioside species in the amphibian Xenopus. Cell Biol. Int. 20/10, 667-672 (1996).

12. R. Gornati, S. Basu, G. Bernardini, A. M. Rizzo F. Rossi and B. Berra. Activities of glycolipid glycosyltransferases and sialidases during the early development of Xenopus laevis. Molecular and Cellular Biochemistry 166, 117-124 (1997).

13. R. Gornati, B. Bembi, X. Tong, R. Boscolo B. Berra. Total glycolipid content in serum and urine of patients with Gaucher's disease type 3 before and after enzyme replacement therapy. CCA, 271, 151-161 (1998).

14. A.M. Rizzo, R. Gornati, F. Rossi, G. Bernardini and B. Berra. Effect of maternal diet on the distribution of phospholipids and their fatty acid composition in Xenopus laevis embryos. J. Nutritional Biochemistry, 10, 44-48 (1999).

15. F. Rossi, R. Gornati, A.M. Rizzo, L. Venturini, G. Bernardini and B. Berra. Glycolipid glycosyltrasferase activities during early development of Xenopus: effect of retinoic acid. Cell Biology International 23 n°2, 91-95 (1999).

16. C. Lindi, G. Montorfano, F. Rossi, R. Gornati and A.M. Rizzo. Effect of ethanol exposure on Xenopus embryo lipid composition. Alcohol & alcoholism 36(5), 388-392 (2001).

17. A.M. Rizzo, F. Rossi, A. Guerra, B. Berra, R. Gornati, G. Bernardini and S. Sonnino. Exogenous sphingosine enters Xenopus laevis embryos grown in petri dishes and it is metabolized. Bioscience Report, 21(6), 719-731 (2001).

18. R. Gornati, B. Berra, C. Martini, G. Montorfano, G. Ciana, P. Ferrari, M. Romano and B. Bembi. Glycolipid analysis of different tissues and cerebrospinal fluid in type 2 Gaucher disease. J. of Inherited Metabolic Disease, 25, 47-55 (2002).

19. D. Vigetti, L. Pollegioni, C. Monetti, M. Prati, G. Bernardini, R. Gornati*. Property comparison of recombinant amphibian and mammalian allantoicases. FEBS Letters, 512, 323-328 (2002).

20. D. Vigetti, C. Monetti, M. Prati, R. Gornati and G. Bernardini. Genomic organization and chromosome localization of the murine and humane allantoicase gene. Gene, 289, 13-17 (2002).

21. C. Monetti, D. Vigetti, M. Prati, E. Sabbioni, G. Bernardini, R. Gornati*. Gene expression in Xenopus embryos after methylmercury exposure: a search for molecular biomarkers. Environmental Toxicology & Chemistry, 21(12) 2731-2736 (2002).

22. R. Gornati,C. Monetti, D. Vigetti, S. Bosisio, S. Fortaner, E. Sabbioni, G. Bernardini and M. Prati. Arsenic toxicity and HSP70 expression in Xenopus laevis embryos. ATLA, 30, 597-603 (2002).

23. A.M. Rizzo, B. Berra, F. Rossi, A. Guerra, R. Gornati, G. Bernardini, T. Taki, T. Kasama, L. Mauri and S. Sonnino. Structure of the main ganglioside from the brain of Xenopus laevis. Glycoconjugate J. 19 (1), 53-57 (2002).

24. D. Vigetti, G. Binelli, C. Monetti, M. Prati, G. Bernardini, R. Gornati*. Selective pressure on the allantoicase gene during vertebrate evolution. J. of Molecular Evolution 57, 650-658 (2003).

25. C. Monetti, G. Bernardini, D. Vigetti, M. Prati, S. Fortaner, E. Sabbioni, and R. Gornati* Platinum toxicity and gene expression in Xenopus embryos: analysis by FETAX and differential display. ATLA, 31(4), 401-408. (2003).

26. D. Vigetti, M. Viola, R. Gornati, M. Ori, I. Nardi, A. Passi, G. De Luca, G. Bernardini. Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3. Matrix Biology, 22/6 pp 511-517 (2003).

27. R. Gornati, G. Terova, D. Vigetti, M. Prati, M. Saroglia and G. Bernardini. Effects of population density on sea bass (Dicentrarchus labrax) gene expression. Aquaculture 230/1 pp 229-239 (2004).

28. R. Gornati*, E. Papis, S. Rimoldi, G. Terova, M. Saroglia and G. Bernardini. Rearing density influences the expression of stress related genes in seabass (Dicentrarchus labrax L.). Gene 341, 111-118 (2004).

29. R. Gornati*, Elena Papis, Simona Rimoldi, Valentina Chini, Genciana Terova, Mariangela Prati, Marco Saroglia, Giovanni Bernardini. Molecular markers for animal biotechnology: sea bass (Dicentrarchus labrax, L.) HMG-CoA reductase mRNA. Gene 344, 299-305 (2005).

30. R. Gornati, S. Gualdoni, R. Cavaliere, G. Terova, M. Saroglia and G. Bernardini. Molecular biology and fish welfare: a winning combination. Aquaculture international 13, 51-55 (2005).

31. G. Terova, R. Gornati, S. Rimoldi, G. Bernardini, M. Saroglia Quantfication of a glucocorticoid receptor is sea bass (Dicentrarchus labrax, L.) reared at high smoking density. Gene

32. Valentina Chini, Simona Rimoldi, Genciana Terova, Marco Saroglia, Giovanni Bernardini, Rosalba Gornati*. EST-based identification of genes expressed in the liver of adult seabass (Dicentrarchus labrax, L.). Accepted in gene.

* “Corresponding Author”
 

 

 

 
 
   
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